Response to: Prenatal smoke exposure, DNA methylation and a link between DRD1 and lung cancer

We thank Ryan and Robles for their interesting comment on our finding that prenatal smoke exposure was associated with DNA methylation levels in adulthood at a CpG site annotated toDRD1.1 In their previous study,2 Ryan and Robles found evidence for a gene –environment interaction between a single nucleotide polymorphism (SNP) inDRD1 and second-hand smoke exposure in relation to lung cancer. They speculate that their observed interaction could be mediated by DNA methylation atDRD1. The SNP they mention (rs686) is located 245  766 base pairs downstream of the identified CpG site (cg22807681) inDRD1.
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research