More Evidence for Neurofilament Light Chain as MS Biomarker More Evidence for Neurofilament Light Chain as MS Biomarker
Tracking sNfL levels over time corresponds to multiple sclerosis disease course in a longitudinal study, but use of the blood biomarker for individual prognosis remains unclear.Medscape Medical News
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): D Marengo, R Rosato, G Gamberini, P Cavalla, M Gironi, F Patti, L Prosperini, C SolaroAbstractBackgroundThe Multiple Sclerosis Walking Scale (MSWS-12) has showed good psychometric properties in reports exploring its validity using Classical Test Theory methods. Findings from recent studies using Item Response Theory methods advance the idea that some aspects of the MSWS-12 does not fully comply with some requirements of sound measurement.Research questionThe present study investigated whether the measurement prope...
ConclusionsExperts compared therapeutic attitudes and practices regarding second-line treatment failure between French regions. They identified convergences that were used to propose a national agreement on second-line treatment failure criteria, which should be evaluated in real-life prospective cohorts.
ConclusionsThis study is the first to investigate possible lncRNA biomarkers to differentiate phenotypic severity in MS. Although the findings are preliminary based on our small sample size, they are sufficient to identify hypotheses for future investigation, and give guidance regarding the design of future studies.
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Afsaneh Shirani, Darin T. Okuda
An association between concussion during adolescence and long-term, elevated risk for multiple sclerosis grew stronger with new evidence from a large study.Medscape Medical News
Authors: Deleu D, Canibaño B, Mesraoua B, Adeli G, Abdelmoneim MS, Ali Y, Elalamy O, Melikyan G, Boshra A Abstract Healthcare systems vary greatly between countries. International, evidence-based guidelines for the management of multiple sclerosis (MS) may need to be adapted for use in particular countries. Two years ago, the authors published a comprehensive consensus guideline for the management of MS in Qatar. Since that time, the availability of disease-modifying treatments for relapsing-remitting MS (RRMS), and our understanding of how to apply those treatments, has increased. The authors present an upd...
Fall prevention requires a multifaceted approach that should include individual risk assessment and intervention strategies. Exercise interventions may mitigate most risk factors for falls (eg, balance impairment, gait impairment, and muscle weakness). Numerous systematic reviews or meta-analyses have assessed the effectiveness of exercise interventions among people with various types of neurological disorders; however, the evidence obtained has not been synthesized into an overview. Therefore, the present systematic review assessed systematic reviews of exercise intervention for fall prevention among people with neurologi...
Condition: Multiple Sclerosis Intervention: Biological: Fecal microbial transplant (FMT) Sponsors: Griffin Hospital; Yale-Griffin Prevention Research Center; Multiple Sclerosis Treatment Center, Derby, Connecticut Recruiting
Women with multiple sclerosis who continued to receive the drug during pregnancy had a much lower risk of relapses, according to a new Italian observational study.Medscape Medical News
No abstract available