Hematopoietic Cell Transplantation in the Treatment of Adult Acute Lymphoblastic Leukemia: Updated 2019 Evidence-Based Review from the American Society for Transplantation and Cellular Therapy

The role of hematopoietic cell transplantation (HCT) for adults with acute lymphoblastic leukemia (ALL) is reviewed and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the recommendations. A panel of ALL experts developed consensus on the treatment recommendations based upon the evidence. Allogeneic HCT offers a survival benefit in selected patients with ALL and this review summarizes the standard indications as well as the areas of controversy.

Source: Biology of Blood and Marrow Transplantation - August 21, 2019 Category: Hematology Authors: Zachariah DeFilipp, Anjali S. Advani, Veronika Bachanova, Ryan D. Cassaday, Daniel J. Deangelo, Partow Kebriaei, Jacob M. Rowe, Matthew D. Seftel, Wendy Stock, Martin S. Tallman, Suzanne Fanning, Yoshihiro Inamoto, Ankit Kansagra, Laura Johnston, Arnon Na Source Type: research