Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication that can develop in patients treated with anti-resorptive drugs. Although the pathogenesis of MRONJ is still unclear, genetic factors have a demonstrated important role. Thus, the aim of this study was to perform a systematic review on the pharmacogenetics of MRONJ. Studies published until March 2019 were retrieved from eight databases and were selected by two independent reviewers. Evidence on several genetic polymorphisms was summarized and a meta-analysis was conducted when possible.

Source: International Journal of Oral and Maxillofacial Surgery - August 21, 2019 Category: ENT & OMF Authors: Z. Guo, W. Cui, L. Que, C. Li, X. Tang, J. Liu Tags: Meta-Analysis Source Type: research