GSE124063 The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

Contributors : Nicholas Collins ; Seong-Ji Han ; Michel Enamorado ; Verena M Link ; Yasmine BelkaidSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes and CXCR4-CXCL12 and S1P-S1P1R interactions contributed to enhanced T cell accumulation in BM during DR. Memory T cell homing to BM during DR was associated with enhanced protection against infections and tumors. Together, this work uncovers a fundamental host strategy to sustain and optimize immunological memory during nutritional challenges that involved a temporal and spatial reorganization of the memory pool within ‘‘safe haven’’ compartments.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research