Do Upper and Lower Camptocormias Affect Gait and Postural Control in Patients with Parkinson's Disease? An Observational Cross-Sectional Study.

In conclusion, lower CC was associated with more severe gait and postural control impairment than patients with upper CC and without CC. Categorizing CC based on the bending fulcrum is compulsory to identify patients with the worst performance and to implement specific rehabilitation programs. PMID: 31428306 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research

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The objective of the current study was to investigate the change in IPS and attention during head-up tilt (HUT) in patients with NOH compared to controls. Cognitive function was assessed in the supine and HUT positions using the symbol digit modalities test (SDMT) which assesses IPS and the Stroop Test which measures attention. 40 participants completed the study, 20 controls (age 64.50 ± 9.25) and 20 NOH patients (age 69.55 ± 7.43) with associated conditions of Parkinson's disease (n = 11), multiple systems atrophy (n = 3), early Lewy body dementia (n = 1) and idiopathic NOH (n = 5). ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
ConclusionRecognition of emotional stimuli was more accurate compared to non-emotional stimuli in AD, left-sided PD and HC; right-sided PD did not show sensitivity to the emotional valence of the stimuli suggesting the involvement of the nigrostriatal, mesocortical and mesolimbic circuitry of the left hemisphere in the emotional-reward system related to the aesthetic experience.
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: Our findings suggest that PTT is beneficial to improve reactive balance in PwPD. Further, PTT appeared to be effective only for a part of PwPD, especially for those with lower balance and cognitive function, which needs further attention.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, PMID: 31517749 [PubMed - in process]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
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Source: Journal of Neurologic Physical Therapy - Video - Category: Physiotherapy Source Type: video
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Source: Journal of Neurologic Physical Therapy - Video - Category: Physiotherapy Source Type: video
AbstractIt has been suggested that extracellular alpha synuclein ( αSyn) can mediate neuroinflammation in Parkinson's disease, and that αSyn affects B‐cell maturation. However, the function of αSyn in T cells is poorly understood. We hypothesized that αSyn can affect CD4+ T ‐cell proliferation and activity. We found that αSyn deficiency exacerbates disease progression in 8 weeks old C57BL6/J EAE‐induced mice, and that αSyn‐deficient CD4+ T cells have increased pro ‐inflammatory response to myelin antigen relative to wild‐type cells, as measured by cytokine secretion of interl...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: This educational program did not reduce the risk of falls but it improved the ability to carry out activities of daily living and decreased participation restrictions in people with neurological conditions.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Transcranial non-invasive brain stimulation (NIBS) techniques include particularly repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), although other non-invasive stimulation techniques have also been employed. The rTMS uses a rapidly changing magnetic field to induce currents and action potentials in underlying brain tissue. The tDCS involves the application of weak (1 –2mA) electrical currents to modulate neuronal membrane potential. Although the precise mechanisms of NIBS aftereffects have not been fully elucidated, rTMS has been shown to modulate several neurotr...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Conclusions:ID comorbid to PD is associated with the classic psychological factors perpetuating ID in neurological disease-free individuals with insomnia. Target-oriented interventions for instance cognitive behavioral therapy for chronic insomnia should be considered as a treatment approach for ID comorbid to PD.Citation:Lebrun C, Gély-Nargeot M-C, Maudarbocus KH, Rossignol A, Geny C, Bayard S. Presleep cognitive arousal and insomnia comorbid to parkinson disease: evidence for a serial mediation model of sleep-related safety behaviors and dysfunctional beliefs about sleep.J Clin Sleep Med. 2019;15(9):1217–1224.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
As is the case for many neurodegenerative conditions, Parkinson's disease is associated with the spread of protein aggregation. Specific proteins become changed in ways that cause them to form solid deposits, surrounded by a halo of associated toxic biochemistry that harms neurons. The aggregates in Parkinson's patients are formed from α-synuclein, and here, researchers provide evidence for the origins of α-synuclein related neurological dysfunction to begin in the intestine, and only later migrate to the brain. Parkinson's disease is characterised by a slow destruction of the brain due to the accumula...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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