A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO 2 removal in a large metropolis area
We report a collaborative initiative in a large metropolis.MethodsTo assess on a structural basis the rate of utilization as well as efficacy and safety parameters of 2 ECCO2R devices in 10 intensive care units (ICU) during a 2-year period.ResultsSeventy patients were recruited in 10 voluntary and specifically trained centers. The median utilization rate was 0.19 patient/month/center (min 0.04; max 1.20). ECCO2R was started under invasive mechanical ventilation (IMV) in 59 patients and non-invasive ventilation in 11 patients. The Hemolung Respiratory Assist System (Alung) was used in 53 patients and the iLA Activve iLA kit (Xenios Novalung) in 17 patients. Main indications were ultraprotective ventilation for ARDS patients (n = 24), shortening the duration of IMV in COPD patients (n = 21), preventing intubation in COPD patients (n = 9), and controlling hypercapnia and dynamic hyperinflation in mechanically ventilated patients with severe acute asthma (n = 6). A reduction in medianVT was observed in ARDS patients from 5.9 to 4.1 ml/kg (p
Conclusions: P. aeruginosa-derived flagellin-induced IL-6 and IL-8 production in bronchial epithelial cells, which partially explains the mechanisms of progression and exacerbation of COPD. Corticosteroids are the most effective treatment for the suppression of flagellin-induced IL-6 and IL-8 production in the bronchial epithelial cells. PMID: 31517562 [PubMed - as supplied by publisher]
Authors: Salhi M, Lahmar O, Salah MO, Banić I, Binghao B, Malik W, Hamzaoui K, Turkalj M, Hamzaoui A Abstract OBJECTIVE: Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the genes identified, we selected glucocorticoid-induced transcript 1 (GLCCI1) and stress-induced phosphoprotein 1 (STIP1) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics. METHODS: We analyzed four single nucleotide polymorphisms (SNPs): two in GLCCI1 (rs37972 and rs37973), and two i...
Authors: Kong I, Zhao Y, Wang Y, Chang X, Cui L, Gu G, Ma Z, Lu Q, Zhou L, Ding L, Wang Z, Shao Y, Tang H, Zhang C, Hui F, Mei X, Xin J, Huo J, Sun S, Zhu S, Yao C, Du G, Cheng M, Kang J Abstract Purpose: The aim of this study was to investigate the efficacy and safety of tratinterol hydrochloride in bronchial asthma(BA) treatment. Methods: Patients enrolled in this study were distributed randomly into a treatment group (tratinterol hydrochloride) and an active control group (procaterol hydrochloride) and were treated for 2 weeks after running-in. The end points were changes in pulmonary function and clinical sympt...
Authors: Cômes J, Prieur G, Combret Y, Gravier FE, Bonnevie T, Medrinal C PMID: 31514554 [PubMed - as supplied by publisher]
Publication date: Available online 13 September 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Qian Ke, Lin Yang, Qinghua Cui, Wenqi Diao, Youyi Zhang, Ming Xu, Bei HeAbstractAirway remodeling is a key pathological lesion in chronic obstructive pulmonary disease (COPD), and it leads to poorly reversible airway obstruction. Current pharmacological interventions are ineffective at controlling airway remodeling. To address this issue, we queried the Connectivity Map (cMap) database to screen for drug candidates that had the potential to dilate the bronchus and inhibit airway smooth muscle (ASM) proliferation. ...
ConclusionsThese results suggest that cross-sectional imaging can help differentiate patients in whom closer follow-up may be warranted after venoplasty and stent placement for MTS and also guide counseling regarding prognosis.
Conclusion: CAT outperformed CCQ and SGRQ, and it increased the explanatory power of VAS. EBV combined with CAT seems superior to only generic or disease-specific approaches. PMID: 31512524 [PubMed - as supplied by publisher]
CONCLUSION: The present study's case of oral anticoagulants in VTE treatment illustrated the importance of the cost perspective in the choice of therapy. If decision-making were based on drug costs only, instead of applying a health care sector or societal cost perspective, suboptimal decisions may be likely. PMID: 31516054 [PubMed - as supplied by publisher]
CONCLUSIONS: MitraClip procedure improved life-years and quality of life in patients at high surgical risk and it was also a cost-effective treatment option. PMID: 31516049 [PubMed - as supplied by publisher]
ConclusionsElevated Six2 expression in HCC tumor patients was associated with negative prognosis. Upregulated Six2 promoted tumor growth and facilitated HCC metastasis via TGF-β/Smad signal pathway.