Cisplatin-resistant MDA-MB-231 cell-derived exosomes increase the resistance of recipient cells in an exosomal miR-423-5p-dependent manner.

CONCLUSIONS: Exosomes from DDP-resistant TNBC cells (231/DDP) altered the sensitivity of other breast cancer cells to DDP in an exosomal miR-423-5p dependent manner. Our research helps to elucidate the mechanism of DDP resistance in breast cancer. PMID: 31424364 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31424364?dopt=Abstract

Source: Current Drug Metabolism - August 18, 2019 Category: Drugs & Pharmacology Authors: Wang B, Zhang Y, Ye M, Wu J, Ma L, Chen H Tags: Curr Drug Metab Source Type: research