Potential Anti-Inflammatory Effect of Escitalopram in Iodoacetamide-Induced Colitis in Depressed Ovariectomized Rats: Role of α7-nAChR

AbstractEscitalopram, a drug of choice in the treatment of depression, was recently shown to possess an anti-inflammatory activity. The aim of the present study was to elucidate the effect of escitalopram on peripheral inflammatory cascades in iodoacetamide-induced colitis associated with depressive behavior in ovariectomized rats. Moreover, the role of α-7 nicotinic acetylcholine receptor in mediating the anti-colitic effect of escitalopram was examined using a nicotinic receptor antagonist methyllycaconitine citrate. Colitis was induced by intracolonic injection of 4% iodoacetamide in ovariectomized rats. Escitalopram (10 mg/kg/day, i.p.) was t hen injected for 1 week and several parameters including macroscopic (colon mass index and ulcerative area), microscopic (histopathology and scoring), and biochemical (myeloperoxidase and tumor necrosis factor-α) were determined. Colitis induction in ovariectomized rats resulted in a marked increa se in colon mass index, ulcerative area, histopathological scoring, myeloperoxidase activity and tumor necrosis factor-α levels. These effects were ameliorated by escitalopram, even in the presence of methyllycaconitine indicating that α-7 nicotinic acetylcholine receptor does not mediate the anti -inflammatory effect of escitalopram. The present study revealed the beneficial effect of escitalopram in iodoacetamide induced colitis in ovariectomized rats and suggests that it may represent a new therapeutic a...
Source: Inflammation - Category: Allergy & Immunology Source Type: research

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Abstract Gut inflammation or injury causes intestinal hypersensitivity (IHS) and hyperalgesia, which can persist after the initiating pathology resolves, are often referred to somatic regions and exacerbated by psychological stress, anxiety or depression, suggesting the involvement of both the spinal cord and the brain. The supraspinal mechanisms of IHS remain to be fully elucidated, however, over the last decades the series of intestinal pathology-associated neuroplastic changes in the brain has been revealed, being potentially responsible for the phenomenon. This paper reviews current clinical and experimental d...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
CONCLUSION: A 37-year-old man developed infusion-related angioedema with use of infliximab-abda. Discontinuation of the biosimilar product along with supportive care brought about resolution of angioedema. There are no prior published reports of infusion-related angioedema reactions secondary to infliximab-abda use. PMID: 33031494 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: Quality of Life Research - Category: Health Management Source Type: research
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Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Publication date: Available online 14 September 2020Source: Journal of ColoproctologyAuthor(s): Carlos Henrique Marques dos Santos, Amanda Cristine Alcântara Galindo, Bárbara Alencar da Silva, Camila Rodrigues Dantas, Isadora Albuquerque de Araújo Guilherme, José Elias Basmage Nunes Gomes, Kayque Michel Dallacqua, Mariana Pereira de Souza, Patricia Szlachta Senna
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
AbstractPatients with inflammatory bowel disease (IDB) may have higher levels of sexual dysfunction than the general population. We aimed to study the prevalence of sexual disorders in a sample of Brazilian male and female patients with IDB and its association with depression, epidemiological and clinical data. This was a cross sectional study of 192 individuals (40 females with IDB, 40 males with IDB and 112 healthy controls). Male patients and controls answered the IIEF-5 (International Index of Erectile Function-5) and female patients the FSFI (Female Sexual Function Index). Beck Depression Inventory-II was used to acce...
Source: Sexuality and Disability - Category: Disability Source Type: research
There is growing evidence that individuals with serious, chronic conditions are at higher risk for symptoms of depression and anxiety. In two recent systematic reviews of psychological distress in individuals with inflammatory bowel disease (IBD) and Type I diabetes, elevated rates of depressive and anxious symptoms were reported by a large percentage of the population. For those with IBD, approximately 22% had elevated symptoms of depression and 35% reported elevated symptoms of anxiety [1]. These rates are similar to those reported by individuals with Type I diabetes, with 30% screening elevated on depression and 32% scr...
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Clinical Trial Paper Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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