A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis

Conclusion: Our study is the first to show that the miR-SNP at PON1 could affect genetic expression and is associated with an elevated risk for ischemic stroke and subclinical atherosclerosis.Highlights: ► T allele carriers of PON1 rs3735590 had lower risk of ischemic stroke. ► T allele carriers had thinner intima-media thickness of internal carotid arteries. ► PON1 is a novel direct target gene of miR-616 by 3′UTR reporter assays. ► The binding ability of miR-616 and PON1 gene expression is regulated by SNP rs3735590.

Source: Atherosclerosis - March 15, 2013 Category: Cardiology Authors: Mu-En Liu, Yi-Chu Liao, Ruey-Tay Lin, Yung-Song Wang, Edward Hsi, Hsiu-Fen Lin, Ku-Chung Chen, Suh-Hang H. Juo Tags: Genetics Source Type: research