A Seroepidemiological Survey of Theileria equi and Babesia caballi in Horses in Mongolia.

The objective of the present study was to investigate the seroepidemiology of T. equi and B. caballi in horses reared in various Mongolian provinces. Serum samples prepared from blood collected from horses in 19 Mongolian provinces were screened for antibodies specific to T. equi and B. caballi using enzyme-linked immunosorbent assays based on recombinant forms of T. equi merozoite antigen-2 and the B. caballi 48-kDa merozoite rhoptry protein, respectively. Of 1,282 horses analyzed, 423 (33%) and 182 (14.2%) were sero-positive for T. equi and B. caballi, respectively. Additionally, 518 (40.4%) were positive for at least 1 parasite species, of which 87 (16.8%) were co-infected with both parasites. Both T. equi and B. caballi were detected in all surveyed provinces, and on a per province basis the positive rates ranged from 19.0 to 74.2% and 4.5 to 39.8%, respectively. Theileria equi- and B. caballi-positive rates were comparable between male horses (31.9 and 14.1%, respectively) and female horses (34.5 and 14.3%, respectively). However, the positive rates were higher in the>3-yr-old age group (37.7 and 15.6%, respectively) compared with the 1-3-yr-old age group (19.4 and 10.0%, respectively). These findings confirmed that T. equi and B. caballi infections are widespread among horses all over Mongolia, and that horse age is a risk factor for infection in this country. Our results will be useful for designing appropriate control measures to minimize T. equi and B. caballi inf...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research

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This study was set to evaluate the presence of EP parasites in domestic donkeys and in wild equids in Israel and the Palestinian Authority (PA). To assess subclinical EP infection in 98 domestic donkeys (Equus africanus asinus), 9 Asiatic wild donkeys (Equus hemionus), 8 zebras (Equus quagga), 7 African wild donkeys (Equus africanus) and 5 mules, were tested using PCR and qPCR. Positive samples were characterized by amplification and sequencing of a 1600 bp fragment of the 18S rRNA gene. Babesia caballi was not detected in any of the animals. Theileria equi was detected in 32% of the donkeys, 89% of Asiatic wild donkeys, 5...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 29 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Catarina Rosa, Masahito Asada, Hassan Hakimi, Ana Domingos, Madalena Pimentel, Sandra AntunesAbstractBabesia species, etiological agents of babesiosis, a recognized emerging tick-borne disease, are a significant animal and human health concern with a worldwide socio-economic impact. The development of genetic manipulation techniques, such as transfection technology, is pivotal to improve knowledge regarding the biology of these poorly studied parasites towards better disease control strategies. For Babesia ovis, responsible for...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Babesia bovis is the causal agent of Asiatic redwater, transmitted by the pandemic tick Rhipicephalus (Boophilus) microplus. Disease control may target the tick vector using acaricides or anti-tick vaccines, or t...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Answer toParasite Case of the Week 558:Plasmodium falciparummalaria,>10% parasitemia. NEGATIVE rapid antigen.Sowhy is the rapid antigen test negative???As noted by our readers, there are many possible reasons for apositive blood smear and negative rapid malaria antigen test (RDT). Here are our options, along with the reasons why each is or isn't a likely explanation in this case:This is babesiosis, and not malaria. This is a very important consideration given the morphologic similarities betweenBabesiaspp. andPlasmodium falciparum.However, the moprhologic features in this case are highly consistent withP. falciparu...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Publication date: Available online 25 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Huseyin Bilgin Bilgic, Selin Hacilarlioglu, Serkan Bakirci, Onur Kose, Ahmet Hakan Unlu, Ayca Aksulu, Metin Pekagirbas, Jabbar Ahmed, Christina Deschermeier, Gordon Langley, Tulin KaragencAbstractBabesiosis is a disease complex caused by unicellular Babesia parasites and among them, malignant ovine babesiosis caused by B. ovis has a devastating economical impact on the small ruminant industry. The control of disease is mainly based on chemotherapy and preventing animals from tick infestation and to date no vaccine is available ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 24 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Umer Chaudhry, Qasim Ali, Imran Rashid, Muhammad Zubair Shabbir, Muhammad Ijaz, Muhammad Abbas, Mike Evans, Kamran Ashraf, Ivan Morrison, Liam Morrison, Neil D. SargisonAbstractPiroplasmosis is caused by tick-borne haemoprotozoa of the genera Theileria and Babesia. These parasitic infections can seriously impact on the health of livestock and production. Piroplasms of multiple species can be present in a single host, but reliable molecular diagnostic tools are needed in order to understand the composition of these complex paras...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
by Luis Miguel Gonz ález, Karel Estrada, Ricardo Grande, Verónica Jiménez-Jacinto, Leticia Vega-Alvarado, Elena Sevilla, Jorge de la Barrera, Isabel Cuesta, Ángel Zaballos, José Manuel Bautista, Cheryl A. Lobo, Alejandro Sánchez-Flores, Estrella Montero Babesiosis is considered an emerging disease because its incidence has significantly increased in the last 30 years, providing evidence of the expanding range of this rare but potentially life-threatening zoonotic disease.Babesia divergens is a causative agent of babesiosis in humans and cattle in Europe. The recently sequenced gen...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 15 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Jiří Černý, Buyantogtokh Buyannemekh, Tersia Needham, Gantulga Gankhuyag, Dashzeveg OyuntsetsegAbstractTicks and tick-borne pathogens (TBPs) pose a considerable threat to human and animal health in Mongolia; a large and sparsely inhabited country whose economy is largely dependent on animal production. Intensive contact between herdsmen and their livestock, together with the use of pastures without fencing, allows contact between wildlife, domestic animals and humans, thus creating ideal conditions for epizoonos...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Abstract The discovery of a plastid in apicomplexan parasites was hoped to be a watershed moment in the treatment of parasitic diseases as it revealed drug targets that are implicitly divergent from host molecular processes. Indeed, this organelle, known as the apicoplast, has since been a productive therapeutic target for pharmaceutical interventions against infections by Plasmodium, Toxoplasma, Babesia, and Theileria. However, some inhibitors of the apicoplast are restricted in their treatment utility because of their slow-kill kinetics, and this characteristic is called the delayed death effect. Here we review ...
Source: Trends in Parasitology - Category: Parasitology Authors: Tags: Trends Parasitol Source Type: research
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