Long-term outcomes in mouse models of ischemia-reperfusion induced acute kidney injury.

Long-term outcomes in mouse models of ischemia-reperfusion induced acute kidney injury. Am J Physiol Renal Physiol. 2019 Aug 14;: Authors: Scarfe L, Menshikh A, Newton E, Zhu Y, Delgado R, Finney C, de Caestecker MP Abstract Severe acute kidney injury (AKI) has a high mortality and is a risk factor for progressive chronic kidney disease (CKD). None of the potential therapies that have been identified in preclinical studies have successfully improved clinical outcomes. This failure is partly because animal models rarely reflect the complexity of human disease: most preclinical studies are short-term, and are commonly performed in healthy, young, male mice. Therapies that are effective in preclinical models that share common clinical features seen in patients with AKI including genetic diversity, different sexes and co-morbidities, and evaluate long-term outcomes, are more likely predict success in the clinic. Here, we evaluated susceptibility to CKD after ischemia reperfusion injury (IRI) with a delayed nephrectomy (DN-IRI) by monitoring long-term functional and histological responses to injury. We define conditions required to induce long-term post-injury renal dysfunction and fibrosis without increased mortality in a reproducible way, and evaluate effect of mouse strains, sexes, and pre-existing diabetes on these responses. PMID: 31411074 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research