Radiation Related Toxicities Using Organ Sparing Total Marrow Irradiation Transplant Conditioning Regimens

Intermediate and long term pulmonary, renal, thyroid, and cataract toxicities are reported in 142 patients after total marrow irradiation (TMI). Mean lung dose of 8 Gy or less is associated with a significant decrease in pulmonary toxicity. IMRT delivery of TMI reduces organ doses and toxicities compared to conventional TBI. Further evaluation of IMRT to deliver TMI, TMLI and organ sparing conformal TBI is warranted.

Source: International Journal of Radiation Oncology * Biology * Physics - August 13, 2019 Category: Radiology Authors: Ashwin Shinde, Dongyun Yang, Paul Frankel, An Liu, Chunhui Han, Bianca Del Vecchio, Timothy Schultheiss, Jonathan Cheng, Richard Li, Daniel Kim, Eric H. Radany, Susanta Hui, George Somlo, Joseph Rosenthal, Anthony Stein, Stephen Forman, Jeffrey Y.C. Wong Source Type: research