Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies.

CONCLUSION: RHD variation in this SCD cohort differs from that reported for African Americans, with increased prevalence of RHD*DAR and underrepresentation of the DAU cluster. Many unexplained Rh antibodies were found in patients with conventional RH allele(s) only. RH genotyping was useful to guide transfusion to determine which patients could potentially benefit from receiving RH genotyped donor units.
PMID: 31408202 [PubMed - as supplied by publisher]

Source: Transfusion - August 12, 2019 Category: Hematology Authors: Dinardo CL, Kelly S, Dezan MR, Ribeiro IH, Castilho SL, Schimidt LC, Valgueiro MDC, Preiss LR, Custer B, Sabino EC, Westhoff CM, NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Tags: Transfusion Source Type: research