Blood Purification and Mortality in Sepsis and Septic Shock A Systematic Review and Meta-analysis of Randomized Trials

Conclusions Very low-quality randomized evidence demonstrates that the use of hemoperfusion, hemofiltration, or plasmapheresis may reduce mortality in sepsis or septic shock. Existing evidence of moderate quality and certainty does not provide any support for a difference in mortality using polymyxin B hemoperfusion. Further high-quality randomized trials are needed before systematic implementation of these therapies in clinical practice.
Source: Anesthesiology - Category: Anesthesiology Source Type: research