Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly

Growth hormone-secreting pituitary adenoma (GHPA), a benign endocrine tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown.

Source: Translational Research - August 9, 2019 Category: Research Authors: Yuanyuan Xiong, Yongjian Tang, Fan Fan, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang Zhang, Zhixiong Liu Source Type: research