Retroperitoneal Teratoma With Malignant TransformationRetroperitoneal Teratoma With Malignant Transformation

This interesting report describes a case of papillary renal cell carcinoma in a metastatic testicular germ cell tumor. BMC Urology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Journal Article Source Type: news

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Authors: Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H Abstract We performed a renal biopsy for nephrotic syndrome in a patient with squamous cell lung carcinoma, which can worsen the prognosis. Chemoradiation therapy was effective for the cancer and proteinuria; we thus inferred that the nephrotic syndrome had been closely associated with the carcinoma. A pathological analysis of the kidney showed monoclonality for λ chain, satisfying the diagnostic criteria of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID); however, con...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 16 October 2019Source: Life SciencesAuthor(s): Abdo A. Elfiky, Alaa IsmailAbstractAimTo work on Hepatitis C Virus (HCV), one of the major causes of liver cirrhosis and hepatocellular carcinoma, polymerase of genotype 4a that have no solved structures deposited in the protein data bank (PDB) yet. Understanding the dynamics and testing some novel inhibitors are also covered.Materials and methodsMolecular Dynamics Simulation (MDS) is performed for a period of 1 μs on comparatively modeled then validated NS5b of subtype 4a. Following MDS analysis, molecular docking is performed to test t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 October 2019Source: Life SciencesAuthor(s): La Hu, Zicheng Zeng, Qing Xia, Zhaoyu Liu, Xiao Feng, Jitao Chen, Mengqiu Huang, Liangcai Chen, Zhiyuan Fang, Qiuzhen Liu, Hongbo Zeng, Xinke Zhou, Jifang LiuAbstractAimsEnhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism of its action linking glucose metabolism with the suppression ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 October 2019Source: Inorganica Chimica ActaAuthor(s): Mahantesh Kumbar, Sangamesh A. Patil, Shivakumar S. Toragalmath, Shailaja S. Jawoor, Arun ShettarAbstractDespite being a polycyclic aromatic compound, fluorenone is not classified as carcinogenic. Some of the derivatives of fluorenone and metal complexes embedded with fluorenone based ligands exhibited challenging biological activities, including anticancer activity. The current investigation hence focuses on synthesis, characterization and anticancer activities of fluorenone based ligands and their coordinate compounds of some firs...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
We present a case of a young male who experienced multiple metastases and been diagnosed HLRCC after the operation of radical nephrectomy for 10 months. This case remains us that early screening and surveillance are recommended to people who have a family history or at risk of HLRCC, surgical and palliative therapy still play an important role in clinical treatment in the meantime.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 October 2019Source: Urology Case ReportsAuthor(s): Kevin Pineault, Ridwan Alam, Alexa Meyer, Michael H. JohnsonAbstractProstatic utricles are rare in the general population and are often otherwise unremarkable anatomic variants. These structures are contiguous with the prostatic urethra and are nevertheless susceptible to urothelial carcinoma. This case report discusses the first reported patient with Fanconi anemia with urothelial carcinoma within an enlarged prostatic utricle.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 October 2019Source: Urology Case ReportsAuthor(s): Akito Ito, Mizuki Hisano, Makoto Takahashi, Naoki Komine, Takaya Abe, Wataru ObaraAbstractA 73-year-old-male patient with hypertension and grade 3B chronic kidney disease underwent radical nephrectomy in the year 2000. As the renal function gradually worsened, the patient was started on hemodialysis in 2003. Eleven years after nephrectomy, the metastases were pointed out. The patient received sunitinib as first-line therapy. Thereafter, as the metastatic lesions became larger, we initiated nivolumab therapy (3 mg/m2 every 2 weeks). Aft...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 October 2019Source: Urology Case ReportsAuthor(s): Ahmed Samet, Mohamed Amine Mseddi, Majed Hamza, Maroua Walha, Ibtissem Bahri, Mourad HadjslimaneAbstractIsolated renal hydatid cyst is rare. Preoperative diagnosis may be difficult because clinical, biochemical and radiologic findings can not eliminate the diagnosis of renal cancer in its cystic form. Open surgery is traditionally the gold standard.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
In conclusion, adult weight gain was associated with increased risk of several major cancers. The degree, timing, and duration of overweight and obesity also seemed to be important. Preventing weight gain may reduce the cancer risk. Link: https://doi.org/10.1093/ije/dyz188
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusion: MDCT provides good results in detecting sinus fat, venous invasion and kidney-confined tumors, but evaluation of perinephric fat remains a difficult task, leading to reduced accuracy in T3a staging. PMID: 31607203 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
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