Paediatric acquired demyelinating syndromes

Acquired demyelinating syndromes of the central nervous system are rare disorders in childhood. Immune-mediated damage affects the myelin sheath of the optic nerves, brain and spinal cord. The majority are monophasic. Relapsing demyelinating syndromes include multiple sclerosis, aquaporin-4 antibody-associated disease and myelin oligodendrocyte glycoprotein antibody-associated disease. The relapsing syndromes are associated with gradual accrual of neurological deficits and cognitive impairment. In this review, we discuss the presentation, diagnosis and management of monophasic and relapsing acquired demyelinating syndromes.
Source: Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Symposium: neurology Source Type: research