Request for medical assistance in dying after a suicide attempt in a 75-year-old man with pancreatic adenocarcinoma.

Request for medical assistance in dying after a suicide attempt in a 75-year-old man with pancreatic adenocarcinoma. CMAJ. 2019 Jul 29;191(30):E838-E840 Authors: Nayyar D, Kawaguchi S, Mah B PMID: 31358598 [PubMed - in process]
Source: cmaj - Category: General Medicine Authors: Tags: CMAJ Source Type: research

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AbstractDespite being one of the most studied cancer-related infections, the relationship betweenHelicobacter pylori infection and gastric adenocarcinoma (GC) remains, in some points, obscure. Based on a critical analysis of the available literature regarding stomach microbiota, we aimed to shed light to a possible new interpretation of the current understanding about theHelicobacter pylori-related GC carcinogenesis. We analyzed data from the literature onHelicobacter pylori and other potential carcinogenic pathogens, in both benignant conditions and gastric adenocarcinoma.Helicobacter pylori is the dominant microorganism ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conclusions sections. Both authors shared in the final refinement of the manuscript. Funding Salary support for WG by National Science Foundation grant 1624615 is gratefully acknowledged. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We gratefully acknowledge very useful comments from Peter Klein on an earlier version of this manuscript, and from the reviewers of this paper, whose comments have resulted in improvements. An earlier version of this...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Samawi HH, Shaheen AA, Tang PA, Heng DYC, Cheung WY, Vickers MM Abstract Background: The risk of suicide is higher for patients with colorectal cancer (crc) than for the general population. Given known differences in morbidity and sites of recurrence, we sought to compare the predictors of suicide for patients with colon cancer and with rectal cancer. Methods: Using the U.S. Surveillance, Epidemiology, and End Results database, adult patients with confirmed adenocarcinoma of the colon or rectum during 1973-2009 were identified. Parametric and nonparametric tests were used to assess selected variables, ...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease. Early Steps in the Tissue Engineering of Intervertebral Discs https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/ In this paper, researchers report on progress towards the manufacture of interver...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Each year, the SENS Research Foundation accepts a group of young life science academics and puts them to work on projects in aging research, both at the foundation and in allied laboratories, creating ties between research groups that can help to advance the state of the art. This year's batch has worked on a diverse set of projects that spread out beyond core SENS initiatives such as allotopic expression of mitochondrial genes. Reading through their projects is a reminder that a great deal can be accomplished these days given a small team, a little funding, and an equipped laboratory. Progress in medical research is no lo...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
by Chun-Nun Chao, Mien-Chun Lin, Chiung-Yao Fang, Pei-Lain Chen, Deching Chang, Cheng-Huang Shen, Meilin Wang Lung adenocarcinoma, the most commonly diagnosed type of lung cancer, has a poor prognosis even with combined surgery, chemotherapy, or molecular targeted therapies. Most patients are diagnosed with an in-operable advanced or metastatic disease, both pointing to the necessity of developing effective therapies for lung adenocarcinoma. Surfactant protein B (SP-B) has been found to be overexpressed in lung adenocarcinoma. In addition, it has also been demonstrated that human lung adenocarcinoma cells are susceptible ...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Background: Macrophages play a key role in neoplastic progression. We recently reported a profound tumor-protective effect of clodronate-mediated macrophage ablation against urethane (a smoke carcinogen)-induced lung oncogenesis (Zaynagetdinov, R. et al. J Immunol 2011;187:5703-11).Aims: To investigate the impact of genetic macrophage ablation on chemical-induced lung tumor development.Methods: Homozygote Dtaf/f mice that express cell-suicidal Diphtheria toxin upon CRE recombinase-mediated recombination were crossed with Lyz2.Cre+/+ mice that express CRE specifically in macrophages. The above controls, as well as double he...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 11.1 Lung Cancer Source Type: research
In this study, MSCs was engineered to express thymidine phosphorylase (TP) which has the capability of converting the prodrug doxifluridine into toxic 5-fluorouracil. TP expression in the MSCs post-transfection of TP cDNA was confirmed by immunoblotting analysis and its activity was determined by spectrophotometric assay. Our results showed the anticancer effectiveness of human HT29 colorectal adenocarcinoma cells co-cultured with TP-expressing MSCs was enhanced with the addition of various dosages of doxifluridine.Citation Format: Nasrin Salehi, Ching-An Peng. Mesenchymal stem cell as delivery carrier for prodrug gene the...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Experimental and Molecular Therapeutics Source Type: research
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