Red blood cell alloimmunization is associated with lower expression of Fc γR1 on monocyte subsets in patients with sickle cell disease.

CONCLUSIONS: Monocytes and the inflammatory milieu increasingly are being appreciated to play a role in some complications of SCD. The differences in FcγR1 expression on monocyte subsets noted between responders and non-responders, which cannot be directly explained by the serum cytokines evaluated, warrant further investigation.
PMID: 31355970 [PubMed - as supplied by publisher]

Source: Transfusion - July 28, 2019 Category: Hematology Authors: Balbuena-Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE Tags: Transfusion Source Type: research