Effects of the Antianginal Drug, Ranolazine, on the Brain Sodium Channel NaV1.2 and Its Modulation By Extracellular Protons

Conclusions and ImplicationsOur work provides novel insights into the modulation of brain sodium channel, NaV1.2, by ranolazine. We demonstrate that ranolazine binds NaV1.2 in a state‐dependent manner, and that the effects of ranolazine are slowed but not abolished by protons. Our results suggest that further research performed on channels with epilepsy‐causing mutations may prove ranolazine to be an efficacious therapy.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fbph.12150

Source: British Journal of Pharmacology - March 8, 2013 Category: Drugs & Pharmacology Authors: C H Peters, S Sokolov, S Rajamani, P C Ruben Tags: Research Paper Source Type: research