Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in prema...

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1342-6

Source: Stem Cell Research and Therapy - July 29, 2019 Category: Stem Cells Authors: J érôme Caron, Véronique Pène, Laia Tolosa, Maxime Villaret, Eléanor Luce, Angélique Fourrier, Jean-Marie Heslan, Samir Saheb, Eric Bruckert, María José Gómez-Lechón, Tuan Huy Nguyen, Arielle R. Rosenberg, Anne Weber and Anne Dubart-Kupperschmit Tags: Research Source Type: research