Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease

Endothelial lipase (EL), a regulator of plasma high-density lipoprotein cholesterol (HDL-C), is secreted as a 68-kDa mature glycoprotein, and then cleaved by proprotein convertases. However, the clinical significance of the circulating EL fragments remains unclear.

Source: Journal of Clinical Lipidology - July 28, 2019 Category: Lipidology Authors: Manabu Nagao, Kazuya Miyashita, Kenta Mori, Yasuhiro Irino, Ryuji Toh, Tetsuya Hara, Ken-ichi Hirata, Masakazu Shinohara, Katsuyuki Nakajima, Tatsuro Ishida Tags: Original Research Source Type: research