SOHO State of the Art Update and Next Questions: Advances in the Treatment of Adult Acute Lymphoblastic Leukemia

The treatment of adult acute lymphoblastic leukemia (ALL) has largely followed the successful pediatric model that uses multi-agent chemotherapy regimens. Although cytotoxic chemotherapy can induce complete remissions, elderly patients are frequently unable to tolerate its intensity owing to toxicities and comorbidities. Elderly patients particularly often relapse, leading to a 5-year overall survival (OS) of only 20%. In an effort to improve outcomes while minimizing toxicities, novel targeted therapies have been developed: monoclonal antibodies against CD19, CD20, and CD22; tyrosine kinase inhibitors; chimeric antigen receptor T-cell therapies; and BH3 mimetics.

Source: Clinical Lymphoma, Myeloma and Leukemia - July 2, 2019 Category: Hematology Authors: Shilpa Paul, Caitlin R. Rausch, Mary Alma Welch, Hagop M. Kantarjian, Elias J. Jabbour Tags: SOHO State of the Art Updates and Next Questions Source Type: research