Sex-related differences in the intratubular renin-angiotensin system (RAS) in 2-kidney 1-clip hypertensive rats.

In conclusion, the female rats were protected from hypertensive renal and cardiac injury after renal artery clipping. An increase in intratubular nonclassic RAS(ACE2/angiotensin 1-7/MasR) and a decrease in the AT1/AT2 ratio could limit the adverse effects of classic RAS during renovascular hypertension in female rats, and estrogen is suggested to play a primary role in the regulation of intratubular RAS components. PMID: 31339773 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research