NIH Awards $10 Million for Acute Flaccid Myelitis Study NIH Awards $10 Million for Acute Flaccid Myelitis Study
The University of Alabama at Birmingham will lead a multicenter natural history study of the polio-like illness that causes muscle weakness and paralysis, primarily in children.Medscape Medical News
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Mohammad Ali, Nisar Ahmad, Haji Khan, Shahid Ali, Fazal Akbar, Zahid Hussain
Delpeyroux RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologou...
[WHO] Following confirmation of circulating vaccine derived polio virus type 2 (cVDPV2) in the environmental sample from Tamale Metropolis and also detection of Polio in a two (2) years, (9) nine months old child from Chereponi district of the North East Region, the Ministry of Health /Ghana Health Service declared the event a Public Health Emergency of National Concern. Again on 25th August 2019, the National Polio Laboratory further notified the Ghana Health Service of confirmation of Polio in environmental su
CONCLUSION: As OPV isn't used in Italy since 2002, recovery of Sabin-like polioviruses indicates the possibility of poliovirus reintroduction, considering also the important exposure to migratory flows. Finally, monitoring the environmental circulation of NPEV, could compensate for the lack of a surveillance system of the infections they cause. PMID: 31517896 [PubMed - in process]
CONCLUSION: The low GMTs and the clear tendency to decrease with increasing age of the subjects, especially against to PV1, confirm the framework of attention that polio is receiving at national and international level. PMID: 31517887 [PubMed - in process]
[Ghana Govt.] The Ghana Health Service (GHS) has started a polio vaccination campaign in the Greater Accra region. The campaign, which started on Wednesday, September 11, 2019, will end on Saturday, September 14, 2019.
After infection with poliovirus, only about 1% of individuals develop paralysis. I have always wondered whether genetic polymorphisms underlie the rarity of this disease outcome. The results of study carried out in Denmark provide the first insights. The study group consisted of 17 individuals who developed poliomyelitis in the pre-vaccine years, 1940-1950, and one who […]
[Premium Times] The Executive Director, National Primary Healthcare Development Agency, Faisal Shuaib, has expressed optimism that Nigeria will not suffer a setback in the success recorded on wild polio eradication in the country.
It may be possible to eradicate malaria—one of history’s deadliest diseases—from the planet by 2050, according to a coalition of 41 leading scientists, economists and health-policy experts writing in the Lancet. “Malaria is one of the oldest and deadliest diseases of humankind,” says Sir Richard Feachem, one of the report’s authors and co-chair of the Lancet commission on malaria eradication. “If we, humankind, were to take on this challenge and eradicate malaria by 2050, it would be an achievement of historic proportions. There would be nothing quite like it.” Malaria, a mos...
CONCLUSION: Clinical data, laboratory results, and neuroimaging findings support the diagnosis of encephalitis and the specific viral etiology. To increase the likelihood of etiologic confirmation, it is important to know the best approach to collecting samples and to choose the best identification technique for each virus. The differential diagnosis of viral encephalitis includes other infections and immune-mediated inflammatory central nervous system disorders. PMID: 31513761 [PubMed - as supplied by publisher]