Acute primary testicular failure due to radiotherapy increases risk of severe postoperative adverse events in rectal cancer patients

Publication date: Available online 19 July 2019Source: European Journal of Surgical OncologyAuthor(s): John Tapper, Stefan Arver, Torbjörn Holm, Matteo Bottai, Mikael Machado, Ravi Jasuja, Anna Martling, Christian BuchliAbstractAimThe aim of this study is to analyze postoperative adverse events (AE) in relation to acute primary testicular failure after radiotherapy (RT) for rectal cancer.MethodThis relation was assessed in 104 men, included in a previous prospective cohort study of men treated with surgical resection of the rectum for rectal cancer stage I-III. Postoperative AE were graded according to Clavien-Dindo (2004). Grade 3 or more was set as cut-off for severe postoperative AE. The impact of primary testicular failure on postoperative AE was related to the cumulative mean testicular dose (TD) and the change in Testosterone (T) and Luteinizing hormone (LH) sampled at baseline and after RT.ResultsTwenty-six study participants (25%) had severe postoperative AE. Baseline characteristics and endocrine testicular function did not differ significantly between groups with (AE+) and without severe postoperative AE (AE-). After RT, the LH/T-ratio was higher in AE+, 0.603 (0.2–2.5) vs 0.452 (0.127–5.926) (p = 0.035). The longitudinal regression analysis showed that preoperative change in T (OR 0.844, 95% CI 0.720–0.990, p = 0.034), LH/T-ratio (OR 2.020, 95% CI 1.010–4.039, p = 0.047) and low T (
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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