Systematic review analysis of robotic and transanal approaches in TME surgery- A systematic review of the current literature in regard to challenges in rectal cancer surgery
Publication date: Available online 15 November 2018Source: European Journal of Surgical OncologyAuthor(s): Julia K. Grass, Daniel R. Perez, Jakob R. Izbicki, Matthias ReehAbstractSeveral patients' and pathological characteristics in rectal surgery can significantly complicate surgical loco regional tumor clearance. The main factors are obesity, short tumor distance from anal verge, bulky tumors, and narrow pelvis, which have been shown to be associated to poor surgical results in open and laparoscopic approaches. Minimally invasive surgery has the potential to reduce perioperative morbidity with equivalent short- and long-...
Source: European Journal of Surgical Oncology (EJSO) - November 16, 2018 Category: Surgery Source Type: research

The number and ratio of positive lymph nodes are independent prognostic factors for patients with major salivary gland cancer: Results from the surveillance, epidemiology, and End Results dataset
ConclusionsOur Results demonstrated that the PLNN and PLNR were independent prognostic indicators for MSGC patients with lymph node metastasis. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 16, 2018 Category: Surgery Source Type: research

Detection of RET rearrangements in papillary thyroid carcinoma using RT-PCR and FISH techniques - A molecular and clinical analysis
ConclusionsFISH analysis, in contrast to hybrid-specific RT-PCR, revealed infrequent and unknown RET fusion genes. The presence of RET rearrangements was associated with a significantly elevated risk to develop iodine refractory disease and lymph node metastases. Of note, significant clinical discrimination was only achievable when taking the FISH results into account; differences would have been missed when using the RT-PCR method only. Increasing evidence of the clinical impact of RET/PTC-positivity may influence the decision on the extent of surgical resection, especially on lymph node dissection, in PTCs. (Source: Euro...
Source: European Journal of Surgical Oncology (EJSO) - November 16, 2018 Category: Surgery Source Type: research

Awareness and management of low anterior resection syndrome: A Dutch national survey among colorectal surgeons and specialized nurses
DiscussionImpact and prevalence of LARS is underestimated by their physicians. Uniform clinical guidelines should be developed to guide physicians in adequate management of patients with LARS. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 14, 2018 Category: Surgery Source Type: research

Stromal characteristics are adequate prognosticators for recurrence risk in ductal carcinoma in situ of the breast
ConclusionsWe were able to validate our previously reported findings regarding the prognostic potential of myxoid periductal stroma in an independent DCIS patient cohort. A CRS based on nuclear grade, myxoid stromal architecture and stromal inflammation might facilitate discrimination of low risk from high risk patients. Consequently, the CRS may tailor adjuvant therapy. Future research should investigate whether radiotherapy can be safely omitted in patients with a low CRS. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 12, 2018 Category: Surgery Source Type: research

Social media, social mania
Publication date: Available online 10 November 2018Source: European Journal of Surgical OncologyAuthor(s): Helen Mohan, Isacco Montroni (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

Awareness and management of low anterior resection syndrome: A Dutch national survey amongst colorectal surgeons and specialized nurses
DiscussionImpact and prevalence of LARS is underestimated by their physicians. Uniform clinical guidelines should be developed to guide physicians in adequate management of patients with LARS. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

A meta-analysis on salvage surgery as a potentially curative procedure in patients with isolated local recurrent or persistent esophageal cancer after chemoradiotherapy
ConclusionsSalvage surgery is a potentially curative procedure in patients with locally recurrent or persistent esophageal cancer and can be performed safely after definitive or neoadjuvant chemoradiotherapy when surgery was initially omitted. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

Oligometastatic gastric cancer: An emerging clinical entity with distinct therapeutic implications
Publication date: Available online 10 November 2018Source: European Journal of Surgical OncologyAuthor(s): Massimiliano Salati, Nicola Valeri, Andrea Spallanzani, Chiara Braconi, Stefano CascinuAbstractGastric cancer (GC) remains responsible for a high burden worldwide being the third leading cause of cancer-related mortality. Most of patients present at an advanced stage at diagnosis and are thus candidate to standard chemotherapy resulting in median survival of less than 1 year. Oligometastatic gastric cancer is an increasingly recognized clinical entity characterized by limited metastatic spread that has been showing to...
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

High CONUT score predicts poor survival and postoperative HBV reactivation in HBV-related hepatocellular carcinoma patients with low HBV-DNA levels
Publication date: Available online 10 November 2018Source: European Journal of Surgical OncologyAuthor(s): Xiao-Bo Wang, Jie Chen, Bang-De Xiang, Fei-Xiang Wu, Le-Qun LiAbstractBackgroundPostoperative hepatitis B virus (HBV) reactivation (PHR) is associated with resection-induced immunosuppression in patients with HBV-related hepatocellular carcinoma (HCC). Controlling Nutritional Status (CONUT) score is an effective index for evaluating immune-nutrition function. However, the value of COUNT in predicting PHR in HBV-HCC patients remains unknown.MethodsTotally, 209 HCC patients were enrolled.ResultsPreoperative immune funct...
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

A personal technical experience and results of a modified end-to-side technique of pancreatojejunostomy: A 350 patients retrospective cohort study
ConclusionsThe mPJ technique is associated with a POPF rate which was less than expected, especially for "difficult" pancreas with high FRS (soft gland texture and small duct). A larger prospective series is needed in addition to comparative studies with other techniques for robust assessment. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 11, 2018 Category: Surgery Source Type: research

Sentinel node for malignant melanoma: An observational study of a consecutive single centre experience
ConclusionsIn this study Breslow thickness was the only independent predictive factor for a positive SN, no predictive factors were identified for NSN. Independent prognostic factors for MSS were SN status, Breslow thickness and ulceration. Interestingly, there was no survival difference depending on SN tumour burden when using 1 mm as cut-off. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 3, 2018 Category: Surgery Source Type: research

Short-term complications in elderly patients undergoing CRS and HIPEC: A single center's initial experience
ConclusionThis retrospective study showed advanced age to be a significant risk factor for SAE > 3, after undergoing CRS and HIPEC. The initial institutional experience resembles previously published literature in terms of severe postoperative morbidity in elderly patients. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 3, 2018 Category: Surgery Source Type: research

LAMB3 is associated with disease progression and cisplatin cytotoxic sensitivity in head and neck squamous cell carcinoma
Publication date: Available online 2 November 2018Source: European Journal of Surgical OncologyAuthor(s): Lihua Liu, Seung-Nam Jung, Chan Oh, Kyungmin Lee, Ho-Ryun Won, Jae Won Chang, Jin Man Kim, Bon Seok KooAbstractObjectivesLaminin subunit beta-3 (LAMB3) is a major component of the basement membrane zone. In our study, we investigated the role of LAMB3 in head and neck squamous cell carcinoma (HNSCC) progression and its clinical implication as a prognostic biomarker.Materials and methodsA retrospective analysis of 100 patients with HNSCC who had undergone curative surgery from 1999 to 2011 was performed. We evaluated LA...
Source: European Journal of Surgical Oncology (EJSO) - November 3, 2018 Category: Surgery Source Type: research

Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience
Publication date: Available online 2 November 2018Source: European Journal of Surgical OncologyAuthor(s): Hidde M. Kroon, John F. Thompson (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 3, 2018 Category: Surgery Source Type: research

Albumin-bilirubin (ALBI) grade-based nomogram to predict tumor recurrence in patients with hepatocellular carcinoma
ConclusionsALBI is a feasible marker for tumor recurrence. This easy-to-use ALBI grade-based nomogram may predict tumor recurrence for individual HCC patient undergoing surgical resection. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 2, 2018 Category: Surgery Source Type: research

Lobectomy vs. segmentectomy. A propensity score matched comparison of outcomes
ConclusionSurgical selection bias could be an important confounder in the selection of patients undergoing segmentectomy. Similar up and down staging were demonstrated in the two groups. This is one of the first studies to investigate the results of segmentectomy versus lobectomy in stage II/IIIa NSCLC tumours. No significant differences were found in functional outcomes, but the survival decreased after 4 years in the segmentectomy group, which could be explained by lower survival in the stage II/IIIa tumours treated with segmentectomy. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 2, 2018 Category: Surgery Source Type: research

The impact of radiological retroperitoneal lymphadenopathy on survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases
ConclusionEnlarged retroperitoneal lymph nodes on a pre-operative CT-scan should not automatically exclude patients from CRS-HIPEC. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - November 2, 2018 Category: Surgery Source Type: research

HIPEC with oxaliplatin for colorectal peritoneal metastasis: The end of the road?
Publication date: Available online 31 October 2018Source: European Journal of Surgical OncologyAuthor(s): Wim CeelenAbstractIn patients with colorectal peritoneal metastases (PM), the use of cytoreductive surgery (CRS) and HIPEC with oxaliplatin (OX) is increasingly used. The results of the recently reported randomized Prodige 7 trial failed to show a difference in overall survival between patients undergoing CRS alone versus CRS combined with HIPEC using high dose OX. The trial was not designed or powered, however, to detect a potentially clinically meaningful benefit in locoregional disease control. Here, I address some ...
Source: European Journal of Surgical Oncology (EJSO) - November 1, 2018 Category: Surgery Source Type: research

D2 lymphadenectomy for gastric cancer as an independent prognostic factor of 10-year overall survival
This study addressed the extension of lymphadenectomy as a prognostic factor of overall survival (OS) for gastric adenocarcinoma (GA).MethodsConsecutive patients who underwent gastrectomy for GA were retrospectively evaluated. Univariate and multivariate models assessed determinants of OS.ResultsFrom 1994 to 2015, 656 consecutive patients who underwent gastrectomy were evaluated. Briefly, 455 (69.4%) were male, 397 (60.5%) underwent total gastrectomy, Roux-en-Y reconstruction was done in 483 (73.6%), and R0 resection was achieved in 632 patients (96.3%). According to multivariate analysis, the risk of death was increased w...
Source: European Journal of Surgical Oncology (EJSO) - October 31, 2018 Category: Surgery Source Type: research

Arpin downregulation is associated with poor prognosis in pancreatic ductal adenocarcinoma
Publication date: Available online 30 October 2018Source: European Journal of Surgical OncologyAuthor(s): Shi-Rong Zhang, Hao Li, Wen-Quan Wang, Wei Jin, Jin-Zhi Xu, Hua-Xiang Xu, Chun-Tao Wu, He-Li Gao, Shuo Li, Tian-Jiao Li, Wu-Hu Zhang, Shuai-Shuai Xu, Quan-Xing Ni, Xian-Jun Yu, Liang LiuAbstractIntroductionArpin (Arp2/3 complex inhibitor), a novel protein found in 2013, plays a pivotal role in cell motility and migration. However, the prognostic value of Arpin in pancreatic ductal adenocarcinoma (PDAC) remains unknown.Materials and methodsWe analyzed the gene expression of ARPIN using the GEO dataset (GSE71989) and val...
Source: European Journal of Surgical Oncology (EJSO) - October 31, 2018 Category: Surgery Source Type: research

Surgical treatment of thoracic dumbbell tumors
ConclusionThoracic dumbbell tumors should be evaluated for intraspinal and neuroforaminal involvement. Single-stage posterior laminectomy plus VATS/thoracotomy, VATS/thoracotomy, and supraclavicular alone or combined with transthoracic approach all could be the preferred method for removing these dumbbell tumors with satisfactory outcomes. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 29, 2018 Category: Surgery Source Type: research

Lung squamous cell carcinoma: A postoperative recurrence analysis of keratinizing and nonkeratinizing subtypes
ConclusionThere were no significant differences of postoperative recurrence between KSCC and NKSCC. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 29, 2018 Category: Surgery Source Type: research

Efficacy and safety evaluation of paclitaxel-loaded metal stents in patients with malignant biliary obstructions
This study aimed to compare differences in efficacy and safety between PECMS/MSCPM and CMS by meta-analysis. A search of PubMed and Embase was conducted for randomized controlled trials of PECMS/MSCPM and CMS in patients with malignant biliary obstructions published between January 1966 and August 2017. A meta-analysis was performed to compare clinical outcomes and complications between stent types. A total of 221 patients from three studies were included. There were no significant differences between PECMS/MSCPM and CMS in stent patency duration (P = 0.128) or survival time (P = 0.363). Risk did not differ between...
Source: European Journal of Surgical Oncology (EJSO) - October 26, 2018 Category: Surgery Source Type: research

Clinicopathological features and prognostic impact of splenic hilar lymph node metastasis in proximal gastric carcinoma
This study aimed to investigate the prognostic impact of no.10 LN metastasis in proximal gastric carcinoma.MethodsWe retrospective reviewed 665 proximal gastric carcinoma patients who underwent total gastrectomy and D2 LN dissection. Clinicopathological features were compared between patients with and without no.10 LN metastasis. The prognostic value of no.10 LN metastasis was examined using Cox prognostic model.ResultsThere were 63 (9.5%) patients with no. 10 LN metastasis. No. 10 LN metastasis only existed in stage III/IV, and was significantly associated with greater curvature/circumferential tumor location, larger tumo...
Source: European Journal of Surgical Oncology (EJSO) - October 26, 2018 Category: Surgery Source Type: research

Prognostic significance of positive circumferential resection margin post neoadjuvant chemotherapy in patients with esophageal or gastro-esophageal junction adenocarcinoma
ConclusionAlthough CRM status is associated with poor outcome, it does not represent an independent prognostic factor. The status of CRM did not significantly influence the pattern of cancer relapse. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 25, 2018 Category: Surgery Source Type: research

Outcomes of surgery for 2010 WHO classification-based intraductal papillary neoplasm of the bile duct: Case–control study of a single Japanese institution's experience with special attention to mucin expression patterns
ConclusionOur 24-year, single institution's experience suggests that Japanese patients with IPNB favorably respond to surgery, even with ICa. MUC5AC and MUC6 expression may be predictive of favorable outcomes. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 25, 2018 Category: Surgery Source Type: research

Effects of CytoReductive surgery plus hyperthermic IntraPEritoneal chemotherapy (HIPEC) versus CytoReductive surgery for ovarian cancer patients: A systematic review and meta-analysis
Publication date: Available online 24 October 2018Source: European Journal of Surgical OncologyAuthor(s): Yizi Wang, Fang Ren, Peng Chen, Shuang Liu, Zixuan Song, Xiaoxin MaAbstractBackgroundThe effects of Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) and CytoReductive Surgery (CRS) for ovarian cancer patients remain controversial.MethodsA systematic review and meta-analysis was conducted using PubMed, Embase and Web of Science databases to investigate Overall Survival (OS), Disease Free Survival (DFS) and adverse effects between HIPEC and CRS group. Results: In our overall analysis (13 studies), patients in the HIPEC ...
Source: European Journal of Surgical Oncology (EJSO) - October 25, 2018 Category: Surgery Source Type: research

Surgical excision versus observation as initial management of desmoid tumors: a population based study
ConclusionsWatchful waiting was successful in 58% of patients, and a further 28% only required one aggressive treatment thereafter, for a total of 86%. Surgery had a favorable recurrence rate (15%), but some recurrences were associated with significant treatment burden. Treatment should be tailored to individual patients in a multidisciplinary setting. A trial of observation appears warranted in most patients.Recurrence rate was not affected by positive margins. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 25, 2018 Category: Surgery Source Type: research

Inter-observer variation in the histopathology reports of head and neck melanoma; a comparison between the seventh and eighth edition of the AJCC staging system
ConclusionReview by a NCI pathologist of histopathologic parameters of primary cutaneous head and neck melanoma led to significant changes in treatment decision. Introduction of the AJCC 8th edition led to slightly less discordances between NCI and non-NCI reports and consequently smaller impact on treatment planning. Expert review remains indicated when a SLNB is considered for additional staging in selected cases. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 25, 2018 Category: Surgery Source Type: research

A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery
ConclusionsThe combined magnetic technique provided accuracy in tumour localization and SN detection without excess tissue excision and with promising results for flexibility in delivery of care. Larger studies are needed to confirm these findings. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 23, 2018 Category: Surgery Source Type: research

High cytoplasm HABP1 expression as a predictor of poor survival and late tumor stage in pancreatic ductal adenocarcinoma patients
Publication date: Available online 21 October 2018Source: European Journal of Surgical OncologyAuthor(s): Zhi-Bo Xie, Lie Yao, Chen Jin, Yi-Fan Zhang, De-Liang FuAbstractBackgroundHyaluronan-binding protein 1 (HABP1) overexpression has been confirmed in different malignancies and found to be strongly associated with tumor development and progression. The aim of the present study was to explore the impact of HABP1 in pancreatic ductal adenocarcinoma (PDAC) patients.MethodHABP1 expression was evaluated in 89 PDAC specimens.ResultsThe expression of HABP1 was significantly higher in tumor tissues than that in adjacent normal t...
Source: European Journal of Surgical Oncology (EJSO) - October 22, 2018 Category: Surgery Source Type: research

Quality of life following urinary diversion: Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors
Conclusioninancial difficulties was the only HRQOL item to differ between the two UD groups. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 22, 2018 Category: Surgery Source Type: research

Is preoperative physical activity level of patients undergoing cancer surgery associated with postoperative outcomes? A systematic review and meta-analysis
ConclusionsThe available literature suggests higher levels of preoperative PA in patients undergoing cancer surgery may be associated with better postoperative outcomes, particularly shorter LOS and better QOL. There is a need for high-quality studies investigating the association between preoperative PA and postoperative outcomes.Systematic review registrationPROSPERO 2017 CRD42017082334. Available from:http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017082334. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 22, 2018 Category: Surgery Source Type: research

PD-1/PD-L1 expressions in medullary thyroid carcinoma: Clinicopathologic and prognostic analysis of Chinese population
ConclusionPD-1/PD-L1 pathway was expressed in MTC patients and was significantly correlated with the distant metastases at surgery, which may shed light on PD-1/PD-L1 as a promising therapeutic target in MTC. Future better understanding of PD-1/PD-L1 expression and their relationship with immunotherapy response may provide direct evidence for management of refractory MTC. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 21, 2018 Category: Surgery Source Type: research

Management of Pt1 tumours removed by endoscopy during colorectal cancer screening: Outcome and treatment quality indicators
ConclusionRisk of nodal involvement in colorectal pT1 tumours is well predicted by known histologic features also in a screening setting, although it was lower than among patients from clinical series. Surgical overtreatment is still significantly present and there is ample room for improvement regarding diagnostic and therapeutic flow-chart. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Prognostic impact of preoperative prognostic nutritional index in Resected advanced gastric cancer: A multicenter propensity score analysis
Publication date: Available online 19 October 2018Source: European Journal of Surgical OncologyAuthor(s): Luo Zeyu, Zhou Lin, Alpha I. Balde, Li Zhou, Linyun He, Cai ZhenWei, ZeNan Zhou, ShengYi Huang, Shuai Han, Min Wei Zhou, Gang Qing Zhang, Zhai CaiAbstractBackgroundAdvanced gastric cancer (AGC) causes debilitating malnutrition and leads to deterioration of the immune response. However, the concept of the prognostic nutritional index (PNI) is controversial when applied to patients with AGC. The aim of the present study was to evaluate the effect of the PNI after gastrectomy in patients with AGC.Materials and MethodsA mu...
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Well differentiated papillary peritoneal mesothelioma treated by cytoreduction and hyperthermic intraperitoneal chemotherapy-the experience of the PSOGI registry
ConclusionsWDPPM can be a lethal disease with substantial recurrence even after aggressive treatment. Patients presenting with extensive disease or disease recurrence after surgical excision are at increased risk for relapse. CRS + HIPEC can be safely applied to WDPPM in specialized centers. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

HER2 as a potential biomarker guiding adjuvant chemotherapy in stage II colorectal cancer
Publication date: Available online 19 October 2018Source: European Journal of Surgical OncologyAuthor(s): Yang Feng, Yaqi Li, Sanjun Cai, Junjie PengAbstractBackgroundHER2 is a well-established therapeutic target in breast and gastric cancers, while the role of HER2 in colorectal cancer is unclear, and no studies have explored the impact of HER2 on the outcome of stage II colorectal cancer patients treated with 5-fluorouracial based adjuvant chemotherapy.MethodsWe analyzed HER2 mRNA expression of 206 patients in GSE39582 dataset and explored the impact of HER2 expression on benefit from adjuvant chemotherapy for stage II c...
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Sentinel node for malignant melanoma: an observational study of a consecutive single center experience
ConclusionsIn this study Breslow thickness was the only independent predictive factor for a positive SN, no predictive factors were identified for NSN. Independent prognostic factors for MSS were SN status, Breslow thickness and ulceration. Interestingly, there was no survival difference depending on SN tumour burden when using 1 mm as cut-off. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Evaluation of the impact of tumor deposits on prognosis in gastric cancer and a proposal for their incorporation into the AJCC staging system
Publication date: Available online 20 October 2018Source: European Journal of Surgical OncologyAuthor(s): Hao Chen, Zhaoqing Tang, Ling Chen, Haojie Li, Xuefei Wang, Fenglin Liu, Yihong SunAbstractBackgroundThe aim of this study was to investigate the prognostic value of tumor deposits (TDs) in patients with gastric cancer after radical gastrectomy.MethodsWe retrospectively reviewed 1518 patients who had undergone radical gastrectomy in Zhongshan Hospital between 2003 and 2011. Correlations between TDs and other clinicopathological characteristics were analyzed. Univariate and multivariate analysis of prognostic factors we...
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

The role of routine histopathology after chest-contouring surgery in transmen
Publication date: Available online 18 October 2018Source: European Journal of Surgical OncologyAuthor(s): Mieke R. Van Bockstal, Stan J. Monstrey, Carolien H.M. van Deurzen (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Wnt targets genes are not differentially expressed in desmoid tumors bearing different activating β-catenin mutations
ConclusionsNo differences in the expression levels of Wnt target genes were observed between the different CTNNB1 mutation types in DTF tumors. Further studies are needed to decipher the mechanism accounting for the diverse disease courses between DTF patients with different CTNNB1 variants. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Postoperative abdominal infections after resection of T4 colon cancer increase the risk of intra-abdominal recurrence
Publication date: Available online 18 October 2018Source: European Journal of Surgical OncologyAuthor(s): Charlotte E.L. Klaver, Karin A.T.G.M. Wasmann, Marlies Verstegen, Jarmila D.W. van der Bilt, Iris D. Nagtegaal, Bert van Ramshorst, Pieter J. Tanis, Albert M. Wolthuis, Hjalmar C. van Santvoort, Johannes H.W. de Wilt, André D’HooreAbstractIntroductionPatients with pT4 colon cancer are at risk of developing intra-abdominal recurrence. Infectious complications have shown to negatively influence disease free survival (DFS) and overall survival (OS) in stage I-III colon cancer. The aim of this study was to det...
Source: European Journal of Surgical Oncology (EJSO) - October 20, 2018 Category: Surgery Source Type: research

Surgical and medical management of small bowel gastrointestinal stromal tumors: a report of the Dutch GIST registry
Publication date: Available online 16 October 2018Source: European Journal of Surgical OncologyAuthor(s): P.A. Boonstra, N. Steeghs, S. Farag, F. van Coevorden, H. Gelderblom, D.J. Grunhagen, I.M.E. Desar, W.T.A. van der Graaf, J.J. Bonenkamp, A.K.L. Reyners, B. van EttenAbstractBackgroundA cohort of 201 patients with small bowel gastrointestinal stromal tumors (GIST) treated between January 1st 2009 and December 31st 2016 in five GIST expertise centers in the Netherlands was analyzed. Goal of this study was to describe the clinical, surgical and pathological characteristics of this rare subpopulation of GIST patients, reg...
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

A predictive model for high/low risk group according to Oncotype DX recurrence score using machine learning
ConclusionWe developed a predictive model using machine learning that could represent a useful and easy-to-access tool for the selection of high ODX RS patients. After additional evaluation with large data and external validation, worldwide use of our model could be expected. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

MRI surveillance for local recurrence in extremity soft tissue sarcoma
ConclusionRoutine MRI surveillance can detect a significant number of clinically undetectable LRs in extremity STS especially for LRs in the thigh or buttock, small LRs or LRs without mass formation. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

The association between Body Mass Index and postoperative complications, 30-day mortality and long-term survival in Dutch patients with colorectal cancer
Publication date: Available online 16 October 2018Source: European Journal of Surgical OncologyAuthor(s): J.H.C. Arkenbosch, F.N. van Erning, H.J. Rutten, D. Zimmerman, J.H.W. de Wilt, S. BeijerAbstractIntroductionThis retrospective study aims to examine the association between body mass index (BMI) and serious postoperative complications, 30-day mortality and overall survival in colorectal cancer (CRC) patients.Materials and methodsAll CRC patients diagnosed between 2008-2013 in the south-eastern part of the Netherlands were included. Patients were categorized into four BMI groups: underweight (
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

Management Of Pt1 Tumors Removed By Endoscopy During Colorectal Cancer Screening: Outcome And Treatment Quality Indicators
ConclusionRisk of nodal involvement in colorectal pT1 tumours is well predicted by known histologic features also in a screening setting, although it was lower than among patients from clinical series. Surgical overtreatment is still significantly present and there is ample room for improvement regarding diagnostic and therapeutic flow-chart. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

Mobile phone apps for the prediction of prostate cancer: external validation of the Coral and Rotterdam apps
ConclusionIn our experience the Rotterdam App outperformed the Coral App for the prediction of prostate cancer or high-grade cancer diagnosis. In particular we confirmed, using the Rotterdam app, that only one out of ten patients with a low Rotterdam score will harbor high-grade prostate cancer on biopsy. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research