Bronchial Thermoplasty Including the Middle Lobe Bronchus Significantly Improves Lung Function and Quality of Life in Patients Suffering from Severe Asthma

This study was approved by the IRB of the University of Essen (No. 17-7356 BO) and registered as a retrospective observational study at the German Clinical Trials Registry (No. DRKS 00011550).ResultsThe median baseline values of FEV1 and Asthma Questionnaire of Life Quality (AQLQ) were 1.33  l (0.91; 1.73) and 3.01 (2.76; 3.61), respectively, and significantly improved 90 days after treatment with FEV 1 at 1.75 l (p-value 0.002) and AQLQ 3.8 (p-value  
Source: Lung - Category: Respiratory Medicine Source Type: research

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Conclusion: Increased cough receptor sensitivity to capsaicin may predict a positive BT response.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Research Letter Source Type: research
CONCLUSION: Our study has shown that omalizumab, effective in the treatment of severe allergic asthma, may also decrease unfavorable structural airway changes in allergic asthmatics, at least with respect to the fibronectin deposit and an increased thickness of the basal lamina. However, more extensive observational studies are needed to verify the above hypothesis. PMID: 30905217 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
ConclusionsIn children with severe, therapy-resistant asthma, BAL granulocyte patterns and infectious species are associated with novel phenotypic features which can inform pathway-specific revisions in treatment. In 32% of children evaluated, BAL revealed corticosteroid-refractory eosinophilic infiltration amenable to anti-Th2 biological therapies, and in 12%, a treatable bacterial pathogen.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
A 42-year-old male patient was referred to hospital with symptoms of shortness of breath, wheezing and dry cough. The patient complains have begun four months ago. Due to them he was diagnosed previously with asthma, and treatment with fixed combination of inhaled corticosteroid and long-acting beta2 agonists was started, but without effect. Laboratory data and chest X-ray conducted in the hospital were normal. The spirometry showed normal FVC, FEV1 and significant reduction of PEF. The flow/volume loop was typically flattened during inspiration and expiration. It was the reason for decision that there is tracheal obstruct...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
ConclusionsChildren with neutrophil-predominant severe asthma have proinflammatory neutrophils with enhanced survival. Airway macrophages are also proinflammatory and dysfunctional and may contribute to global innate immune impairment. Therapies that target neutrophils and related inflammation may be warranted in this subset of children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsChildren with neutrophil-predominant severe asthma have pro-inflammatory neutrophils with enhanced survival. Airway macrophages are also pro-inflammatory and dysfunctional and may contribute to global innate immune impairment. Therapies that target neutrophils and related inflammation may be warranted in this subset of children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Cryotherapy is used mainly in palliation of central airway tumors, cryobiopsy and foreign body removal, but also in treatment of benign conditionsThe aim of the study is to present our experience in using cryotherapy in treatment of granulation tissue following post-intubation stenosisIn period of 2011-2016. in Bronchoscopy Department of University Hospital for Pulmonology in Belgrade, we performed 27 such interventions for postintubation stenosis (PIS) using both flexible and rigid cryoprobe.In 8 patients (pts) PIS was discovered less than 3 weeks after initial intubation; in 3 pts unsuccessful weaning from mechanical ven...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
ConclusionsThese data support the safety of BT and suggest extended efficacy.
Source: QJM - Category: Internal Medicine Source Type: research
Abstract In the 21(st) century inhaled corticosteroids (ICS) have become the mainstay of asthma control. Similarly, ICS are recommended as an add-on therapy to long-acting beta agonists and anti-cholinergics in moderate to severe chronic obstructive pulmonary disease (COPD) with recurrent exacerbations. Ultimately this clinical practice has led to widespread use of ICS, supported by a more favorable side effect profile than that of systemic steroids. However, high doses of ICS and the prolonged duration of the therapy may affect the airways adversely. What is considered to be a "high dose" may vary depen...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Boston Scientific (NYSE:BSX) has launched its Alair bronchial thermoplasty therapy in India, according to an India Blooms report. The device won clearance in the country with indications for treating severe, persistent, drug-resistant asthma in adult patients who’s asthma is not well controlled with inhaled corticosteroids and long acting beta antagonists. Marlborough, Mass.-based Boston Scientific’s Alair bronchial thermoplasty treatment uses a bronchoscope to deliver radiofrequency energy to reduce the amount of excess smooth muscle tissue in the airways. “There are over 18 million estimated a...
Source: Mass Device - Category: Medical Devices Authors: Tags: Regulatory/Compliance Respiratory Boston Scientific Source Type: news
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