Regional grey matter volume links rest-activity rhythm fragmentation with past cognitive decline

Human activity follows 24-hour cycles known as the rest-activity rhythm (RAR). Early research found greater RAR fragmentation in people with dementia1. Since RARs are measured non-invasively and are potentially modifiable, understanding the neurobiology of their relationship with cognition is a step towards biologically-informed screening and prevention. Neurodegenerative (amyloid-related2) and cerebrovascular3 processes have been implicated. However, to our knowledge, no prior studies have evaluated whether grey matter and/or cerebrovascular measures explain statistical correlations between RAR fragmentation and cognition.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Brief Report Source Type: research