Loss of Primary Cilia Increases Polycystin-2 and TRPV4 and Appearance of a Non-selective Cation Channel in Mouse Cortical Collecting Duct.

In conclusion, the 23 pS exist in vivo and activity of this channel are elevated with loss of cilia, consistent with previous finding of an elevated-unregulated calcium permeable pathway at the apical membrane of CD cells that lack cilia.
PMID: 31313950 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - July 16, 2019 Category: Physiology Authors: Saigusa T, Yue Q, Bunni MA, Darwin Bell P, Eaton DC Tags: Am J Physiol Renal Physiol Source Type: research