Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma

Tralokinumab is an anti –interleukin (IL)-13 monoclonal antibody investigated for the treatment of severe, uncontrolled asthma in two Phase III clinical trials, STRATOS 1 and 2. The STRATOS 1 biomarker analysis...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Technical advance Source Type: research

Related Links:

ConclusionsThe benefits of FENO-based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Publication date: Available online 17 August 2019Source: Life SciencesAuthor(s): Paulina Kleniewska, Rafal PawliczakAbstractBronchial asthma and obesity are common health problems. Obesity is already responsible for 300,000 deaths per year.AimsThe aim of the present study was to assess whether apocynin, alpha lipoic acid and probiotic administration in combination with low-fat diet supplementation influences the levels of antioxidant enzymes in the pulmonary tissues of obese asthmatic mice.Main methodsThe study was performed on male C57/BL6 mice divided into 10 groups: (I) control; (II) asthma; (III) obesity; (IV) asthma‚Ä...
Source: Life Sciences - Category: Biology Source Type: research
AbstractTerminalia chebula Retz. (Fam: Combretaceae) (TC) is widely used in traditional system for the treatment of fever, asthma, urinary diseases, and rheumatism. The aim of the present study is to evaluate the efficacy of hydrolysable tannin-rich fraction (HTF) isolated fromTC fruits in collagen-induced arthritic BALB/c mice. Type II collagen-induced arthritis was attained in BALB/c mice. HTF treatment at three gradual doses (100, 200, and 400  mg/kg) was started from 24th day on daily administration up to 4 weeks. Body weight, food intake, and increase in hind paw were monitored at weekly basis. At the end of...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Tarazona-Meza CE, Nicholson A, Romero KM, Pollard SL, Gálvez-Davila RM, Hansel NN, Checkley W Abstract Rationale: Prior evidence suggests that there may be an association between asthma and food insecurity. We sought to describe the prevalence of food insecurity access, defined as having sufficient resources for appropriate foods in Lima, Peru, and evaluate its association with asthma status and control. Methods: We analyzed data from 553 children with asthma and 268 healthy controls aged nine to 19 years living in two peri-urban communities in Lima, Peru, in 2013. We used the Household Food ...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
This article explores the most relevant issues facing the role of e-Health and its sub-category—mobile health (mHealth)—in promoting treatment adherence in childhood asthma, focusing on current evidence gaps and limitations, and future research perspectives.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsPrognosis in patients with CRSwNP was inferior to that in patients with CRSsNP. Asthma was the only factor that increased the chance of recurrence in patients with either CRSsNP or CRSwNP.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionThis study identified multiple SCZ associated genes and pathways, supporting the implication of nuclear acid methylation in the pathogenesis of SCZ.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
The first reason flows from the following release for the Federal Health Department.Building a Mentally and Physically Healthy AustraliaDelivering the world ’s best mental health system – stigma-free and focused on prevention, starting with children under 12 – is the major focus of the Australian Government’s Long Term National Health Plan, outlined today. Date published: 14 August 2019Delivering the world ’s best mental health system – stigma-free and focused on prevention, starting with children under 12 – is the major focus of the Australian Government’s Long Term Nat...
Source: Australian Health Information Technology - Category: Information Technology Authors: Source Type: blogs
This study aimed to assess the impact of inhaler technique education delivered by pharmacists on patients' inhaler technique, Asthma Control Test (ACT) score, forced expiratory volume in the first 1 second (FEV1%), and reliever use (puffs/day). Methods: A pre-post interventional study was conducted over 6 months from February 2017 to July 2017 in rural areas in Jordan. Asthma patients visiting respiratory clinics and using metered dose inhaler (MDI) or turbuhaler (TH) controlled medication were randomly recruited. Inhaler technique was assessed via published checklists. The ACT, FEV1%, and reliever use (puffs/day) were...
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
More News: Asthma | Clinical Trials | Genetics | Respiratory Medicine | Statistics