Imaging Biometrics points to brain tumor study

Advanced visualization software developer Imaging Biometrics is touting a recent...Read more on AuntMinnie.comRelated Reading: Imaging Biometrics teams with CorTechs Labs Imaging Biometrics debuts IB Server software Imaging Biometrics touts research paper on DSC MRI Imaging Biometrics and EnvoyAI announce partnership Imaging Biometrics lands Stanford installation
Source: Headlines - Category: Radiology Source Type: news

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Authors: Chen BS, Wang KY, Yu SQ, Zhang CB, Li GZ, Wang ZL, Bao ZS Abstract Gliomas are the most common type of primary brain tumor in adults with a high mortality rate. Low-grade gliomas progress to glioblastoma multiforme (GBM) in the majority of cases, forming secondary GBM (sGBM), followed by rapid fatal clinical outcomes. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1)-MET proto-oncogene receptor tyrosine kinase (MET) (ZM) fusion has been identified as a biomarker for sGBM that is involved in glioma progression, but the mechanism of gliomagenesis and pathology of ZM-negative sGBM has remained to be full...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusion: The integrated robotic system can place NBTU ablator at a desired target location in porcine brain and monitor the ablation in realtime via magnetic resonance thermal imaging (MRTI). Significance: Further optimization of this system could result in a clinically viable syste- for use in human trials for various diagnostic or therapeutic neurosurgical interventions.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Glioblastoma (GBM) is the most common and aggressive adult primary brain tumor [1,2]. Although radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) has increased patient survival, long-term prognosis remains poor, with a median survival of 15 months [3,4]. Tumor progression most often occurs inside the irradiated tumor volume [5], showing the high radioresistance of these tumors. Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in the regulation of cell proliferation, survival and differentiation.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
In this study, the syngenic, orthotopic GL261 mouse glioma model was used to evaluate the effects of KD on the metabolic responses of the tumor using 7T magnetic resonance imaging/spectroscopy. GL261 cells were injected into the caudate nucleus of mice. Following implantation, animals were fed with standard chow or underwent a KD. 18 days after initiating the diet, mice fed with KD displayed significantly higher plasmatic levels of ketone bodies and survived longer than those fed with the standard diet. Decreased concentrations of gamma-aminobutyric acid, N-Acetyl-Aspartate and N-acetylaspartylglutamate were found i...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
In conclusion, we describe a straightforward ex vivo system mimicking the in vivo situation of the tumor mass and the normal brain in GBM patients. It reduces animal studies and allows for the direct and reproducible application of test drugs and the precise quantitation of their effects on the bulk tumor mass and on the tumor’s invasive properties.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, a multifunctional platform that enables the highly efficient formation of 3D multicellular cancer spheroids and precise real ‐time assessments of the anticancer effects of curcumin in a brain tumor coculture model is reported. A highly conductive gold nanostructure (HCGN) is fabricated to facilitate cancer spheroid formation without using anti‐cell adhesion molecules. A neuroblastoma (SH‐SY5Y) and glioblastoma (U‐ 87MG) coculture model is generated on HCGN with a specific cell‐to‐cell ratio (SH‐SY5Y: U‐87MG = 1:1), and their redox behaviors are successfully measured without destroying the dis...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
AbstractStereotactic biopsies are an established tool for obtaining diagnosis of unclear brain lesions. However, non-diagnostic biopsies still occur. We aimed to analyze the contemporary diagnostic yield of stereotactic biopsies, predictors for non-diagnostic biopsies, outcome, and follow-up strategy after non-diagnostic biopsy. We conducted a single-center retrospective study of 311 adult patients undergoing stereotactic biopsies due to a newly diagnosed lesion at our department between 2012 and 2018. Patient data regarding comorbidities, presenting symptoms, imaging features, and non-invasive diagnostic procedures were o...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
In conclusion, TMEM45A is an oncogenic gene in glioma. The proliferation, migration, and invasion of gliomas could be effectively impeded by inhibition of TMEM45A, and the cancer-promoting effect of TMEM45A on gliomas was involved with the NFκB pathway.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Brain tumors are the most common solid cancer in children younger than 15 years old.[1] Radiation therapy (RT) remains integral to the treatment of pediatric brain tumors, having significantly improved disease prognosis for common malignant tumors such as medulloblastomas: in average-risk disease, the 5-year survival for these tumors is now at 70-80%.[2,3] Elevated 5-year survival rates have also been achieved through the use of RT as a stand-alone therapy in the treatment of germinomas.[4] Despite having contributed to the overall survival benefit experienced by patients, such therapeutic approaches are associated with lo...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
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