Embryonic ketamine produces a downregulation of prefrontal cortex NMDA receptors and anxiety-like behavior in adult offspring

In conclusion, our results suggested that embryonic ketamine treatment induced anxiety-like behavior and the downregulation of NMDAR function in PFC in the adulthood period of offspring, which might result from the enhanced function of NMDARs in the hippocampus at the 4-week juvenile timepoint.
Source: Neuroscience - Category: Neuroscience Source Type: research