Big data analysis of associations between patient reported outcomes, observer reported toxicities, and overall quality of life in head and neck cancer patients treated with radiation therapy

Patient reported outcomes (PROs) have become a common component of data collection in clinical trials in oncology in recent years [1 –8]. They can provide information about treatment toxicity that is complementary to the observer-reported Common Terminology Criteria for Adverse Events (CTCAE) rating system that is typically employed in US-based oncology trials [9]. Although the CTCAE system is essential for assessing the safety of treatments being investigated, studies generally show only fair to moderate associations between clinician and patient reported outcomes, with clinicians typically underestimating symptom severity as rated by patients [10–15].

Source: Radiotherapy and Oncology - May 21, 2019 Category: Radiology Authors: Joel R. Wilkie, Michelle L. Mierzwa, John Yao, Avraham Eisbruch, Mary Feng, Grant Weyburne, Xiaoping Chen, Lynn Holevinski, Charles S. Mayo Tags: Original Article Source Type: research