Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia

Conclusions This study shows that low-dose (30-mg) dextromethorphan is antihyperalgesic in humans on the areas of primary and secondary hyperalgesia and reverses peripheral and central neuronal sensitization. Because dextromethorphan had no intrinsic antinociceptive effect in acute pain on healthy skin,N-methyl-d-aspartate receptor may need to be sensitized by pain for dextromethorphan to be effective.
Source: Anesthesiology - Category: Anesthesiology Source Type: research

Related Links:

We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Contributors : F édéric Torossian ; Christophe Desterke ; Bernadette Guerton ; Jean-Jacques Lataillade ; Marie-Caroline Le Bousse-KerdilèsSeries Type : Expression profiling by arrayOrganism : Homo sapiensHeterotopic Ossification (HO) is the abnormal formation of ectopic bone in soft tissues generally in muscles surrounding joints such hip, knee, elbow or shoulder. The etiology of this pathology is not known but it is well established that the risk of HO is increased after traumatic brain or spinal cord injuries and also after fractures or burns. Patients with HOs suffer from pain and the range of motio...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
It is a great privilege to have developed this issue of the Physical Medicine and Rehabilitation Clinics of North America dedicated to upholding Abraham Lincoln ’s declaration during his second Inaugural Address, “To care for him who shall have borne the battle and for his widow, and his orphan,” by focusing on the specialized rehabilitation needs of Polytrauma Rehabilitation in the Military and Veteran Populations. Polytrauma, defined as “two or mo re injuries, one of which may be life threatening, sustained in the same incident that affect multiple body parts or organ systems and result in physica...
Source: Physical Medicine and Rehabilitation Clinics of North America - Category: Rehabilitation Authors: Source Type: research
Not only the experience of sporting activities and events, but also rehabilitation after sports injuries are changing due to cutting-edge technologies. In sports medicine, the future holds a shift towards prevention through genomics, nutrigenomics, countless trackers, and wearables, while there are many great technologies which aim to alleviate the pain and shorten the time of recovery – if, against all odds, a sports injury still happens. Technology will change the experience of sports injuries and rehabilitation When was the last time you went out for a run without Endomondo or had a bike tour without Strava? Have ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AR exoskeleton genomics health sensors Healthcare nutrigenomics prevention rehabilitation sports sports medicine trackers virtual reality VR wearables Source Type: blogs
Conclusions: PRP is effective in treating burn-induced neuropathic pain and may be used in clinical practice. PMID: 29483815 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
CONCLUSIONS: AD may commonly occur with relative tachycardia. While further investigation is needed on the effects of chronicity of SCI and pharmacologic management, this study raises multiple directions for future research to understand clinical signs and treatment variables of AD following SCI. PMID: 28784041 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Spinal cord stimulation (SCS) is used to treat neuropathic pain, but there are no published studies on its use to treat burn pain. We used SCS to treat a 67-year-old man suffering from burn pain that could not be managed with high-dose opioids or adjuvant neuropathic analgesics. A trial of SCS markedly reduced the visual analog scale score for pain in the left lateral abdominal and gluteal regions. He underwent permanent implantation of a SCS and achieved an opioid-free state. This case suggests that SCS treatment is a therapeutic option for burn pain refractory to conventional therapy.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research
Publication date: May 2017 Source:PM&R, Volume 9, Issue 5, Supplement Author(s): Adam S. Tenforde, Jaye E. Hefner, Jodi E. Kodish-Wachs, Mary A. Iaccarino, Sabrina Paganoni Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and ...
Source: PMandR - Category: Rehabilitation Source Type: research
No abstract available
Source: Pain - Category: Anesthesiology Tags: Correspondence Source Type: research
Robotics has the power to completely reshape the landscape of healthcare both in its structure and its operation. Here, you find my own list about the most relevant companies and start-ups on the healthcare robotics market. With robotics for the sustainability of healthcare As I outlined in my open letter to regulators, the long-term sustainability of healthcare systems could be solved by automation powered by digital health technologies, such as artificial intelligence, 3D-printing or robotics. The latter could take over monotonous work from healthcare workers, which would allow them to focus more on patients and to have ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Medical Robotics GC1 google Health Healthcare Innovation pharma robot companion surgical robot Source Type: blogs
More News: Anesthesia | Anesthesiology | Back Pain | Brain | Burns | Neurology | Pain | Skin | Spinal Cord Injury | Study