MicroRNA ‐125b Regulates Fibroblast Apoptosis Proliferation in Systemic Sclerosis

ConclusionMiR ‐125b is downregulated in SSc skin and primary SSc dermal fibroblasts. MiR‐125b downregulation increases apoptosis, decreases proliferation and αSMA expression in dermal fibroblasts indicating a compensatory, anti‐fibrotic mechanism as a potential novel therapeutic option.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - July 15, 2019 Category: Rheumatology Authors: Anastasiia Kozlova, Elena Pachera, Britta Maurer, Astrid J üngel, Jörg H.W. Distler, Gabriela Kania, Oliver Distler Tags: Full Length Source Type: research