Researchers find anorexia genetic variants, redefine it as metabolic and psychiatric

(University of North Carolina Health Care) The large-scale genome-wide association study, led by UNC's Cynthia M. Bulik, Ph.D., FAED, founding director of the UNC Center of Excellence for Eating Disorders, and Gerome Breen, Ph.D., of King's College London suggests that the origins of the eating disorder include a combination of metabolic and psychiatric components.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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I was diagnosed with anorexia nervosa over a decade ago. Blinded by the eating disorder to the damage that was occurring both internally and externally, the possibility of infertility did not occur to me. When I married at 21, my husband and I both dreamed of one day becoming parents and I lived in this optimism for some time. However, after my periods stopped for 7 years, I began to doubt if being a mother would ever be my reality.  As an eating disorder patient, I had been regularly informed of the risk factors of my illness, some of which included amenorrhoea, the absence of menstruation, and a high chance of infer...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Eating Disorders Personal Pregnancy Infertility Source Type: blogs
ConclusionWeekly 5-FU –leucovorin with biweekly bevacizumab may be a tolerable and effective treatment option for older or frail patients with mCRC.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractObjectiveThe aim of the study was to investigate the outcomes and prognostic factors of high-dose131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.MethodsWe retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent131I-MIBG therapy with an administration dose ranging from 444 to 666  MBq/kg at Kanazawa University Hospital, Japan, between September 2008 and September 2013. We focused on measurements regarding their initial responses, prognostic factors, survivals, and toxicities following131I-MIBG therapy usin...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Condition:   Anorexia Nervosa Intervention:   Other: Measure of body composition by Air Displacement Plethysmography (ADP) Sponsor:   Hospices Civils de Lyon Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, we show that BMAT is inversely associated with WBC and RBC in premenopausal women, and there is a potential association between longitudinal changes in BMAT and changes in RBC. These associations warrant further study and may provide further insight into the role and function of this understudied adipose depot. © 2020 American Society for Bone and Mineral Research.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
This Mini-Review presents recent research into evidence for psychological treatments for people with severe and enduring anorexia nervosa (SEAN). Two psychological therapies, specialist supportive clinical management (SSCM), and cognitive behavior therapy for anorexia nervosa (CBT-AN) have limited (one randomized controlled study) evidence of efficacy. Both have had adaptations for SEAN, notably with revision of the primary treatment goal of improved quality of life and full weight recovery a secondary goal. A major issue with existing studies is poor definition of SEAN, and the large deficit in research that has used an a...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractIndian star tortoise (Geochelone elegans Schoepff, 1795) is a terrestrial herbivorous reptile that is classified under the vulnerable species of IUCN-Red List. The present communication reports the successful management of gastrointestinal parasitism due to co-infection with oxyurids and ascarid nematodes in the captive population of Indian star tortoise maintained at Zoological Garden, Thiruvananthapuram, Kerala, India. The diseased tortoise exhibited clinical signs like diarrhea, anorexia, and weight loss. Direct microscopic examination of pooled fecal sample identified the presence of oxyurid and ascarid ova. Th...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Eating disorders build themselves on perceived feelings of control. Yet, as we find ourselves in the midst of unprecedented and uncertain times, with the coronavirus pandemic, how do those with eating disorders manage? As an individual with an eating disorder, I struggle with the Christmas season, mostly as my ‘safe’ foods are suddenly superseded with aisles of turkeys and potatoes and normal life grinds to a halt for a day as shops close and families and friends gather at home. Coronavirus feels like this, but every single day and on a much bigger scale.  Food aisles are being stripped bare by panic ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Binge Eating Bulimia Eating Disorders Motivation and Inspiration Personal coronavirus COVID-19 Isolation social distancing Source Type: blogs
Conclusions: Findings from a few robust randomized controlled trials suggest that nabilone might be useful for the treatment of agitation in patients with dementia, but there is no convincing evidence for THC. Additional studies are needed to further clarify and assess the benefits of these treatments.Clinical Implications: There were no randomized controlled trials investigating the use of cannabinoids for the treatment of cognitive decline in dementia. Studies on THC reported no significant improvement in agitation. It may be too early to postulate that cannabinoids have any effect on dementia symptoms or their progressi...
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
Distorted representation of one's own body is a diagnostic criterion and corepsychopathology of disorders such as anorexia nervosa and body dysmorphic disorder. Previousliterature has raised the possibility of utilising physical activity intervention (PI) as atreatment option for individuals suffering from poor body satisfaction, which is traditionallyregarded as a systematic distortion in “body image.” In this systematic review,conducted according to the PRISMA statement, the evidence on effectiveness of PI on body representation outcomes is synthesised. We provide an update of 34 longitudinal studies evaluati...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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