Why Prasugrel is contraindicated in TIA ?

  Take Our Poll Current prescribing information cautions clearly Prasugrel should not  be used in TIA  or recent  stroke (Even in  ischemic strokes -Embolic included !) The warning  is perplexing and illogical to me. What is your take ? I would imagine the following  could be  the reasons. Prasugrel  as an  antiplatlet agent is  many fold  powerful and could convert all  strokes into hemorrhagic one . Does Prasugrel convert a TIA into stroke instead of curing it ? Prasugrel may worsen the stroke  in case the TIA is going to end up as stroke. Is there any thing called hemorrhagic TIA ? Since we do not have any mechanism to diagnose Ischemic TIA from hemorrhagic TIA ,  it is better to avoid Prasugrel . It is still a mystery ,  why  clopidogrel which acts on the same receptor and can be safely given for TIA ( pro actively) After thought I think Neuro physicians must answer this question . ( Cardiologists  better limit their extended geographical terrain ! )
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: stroke Uncategorized Antipaltelet agents drugs controversy antipaltelt agents mainstay in tia prasugrel for tia prasugrel vs clopidogrel in TIA strke in evolution Source Type: blogs