High NF-E2-related factor 2 expression predicts poor prognosis in patients with lung cancer: A meta-analysis of cohort studies.

High NF-E2-related factor 2 expression predicts poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radic Res. 2019 Jul 12;:1-281 Authors: Yang Q, Deng H, Xia H, Xu M, Pan G, Mao J, Tao S, Yamanaka K, An Y Abstract NF-E2-related factor 2 (Nrf2) plays an important role in tumor proliferation and chemoresistance. Nrf2 expression levels may be associated with prognosis of lung cancer, but previous results have been inconsistent. Pooled hazard ratios (HRs) and odds ratios were calculated to assess the prognostic value of the Nrf2 expression in this meta-analysis. Nine studies with 940 patients were included. A high Nrf2 expression level was significantly related to decreased overall survival (HR = 1.948, 95% CI = 1.564-2.427), lower response rate (HR = 2.675, 95% CI = 1.553-4.610), and poor progression-free survival (HR = 3.078, 95% CI = 1.791-5.293). Subgroup analysis demonstrated that high-Nrf2-expression was significantly correlated with worse overall survival (OS) of patients possessing epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or undergoing chemotherapeutic treatments (HR = 2.500, 95% CI = 1.556-4.018). Conversely, this high expression was not significantly related to the OS of patients with surgical resection (HR = 1.750, 95% CI = 0.995-3.080, and p = 0.052). High Nrf2 expression was significantly correlated with worse OS of patients in advanced st...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research