High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NF κB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

Metabolic diseases, such as diabetes mellitus type 1 (T1DM) and type 2 (T2DM) and metabolic syndrome (MetS) affect all aspects of lipid metabolism. Among others, the bioconversion (desaturation, elongation, β-oxidation) of fatty acids is also affected [1]. Bioconversion of fatty acids is a highly regulated process controlled by the activity of desaturases and elongases, metabolites, transcriptional factors, substrate availability (dietary fatty acids and dietary n6/n3 ratio), microRNA and β-oxidation (mitochondrial and peroxisomal) [2].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 11, 2019 Category: Biomedical Science Authors: Kristina Star čević, Petra Roškarić, Marcela Šperanda, Mislav Đidara, Andrea Gudan Kurilj, Maja Maurić, Tomislav Mašek Source Type: research