Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway

Conclusions: These data indicate that AGEs-induced macrophage migration is dependent on HPA involving RAGE-HPA-PI3K/AKT pathway. The nonenzymatic activity of HPA may play a key role in AGEs-induced macrophage migration associated with inflammation in diabetic vascular complication.

http://www.cardiab.com/content/12/1/37

Source: Cardiovascular Diabetology - February 26, 2013 Category: Cardiology Authors: Qiaojing QinJianying NiuZhaoxia WangWangjie XuZhongdong QiaoYong Gu Source Type: research