Alternate day feeding leads to improved glucose regulation on fasting days without significant weight loss in genetically obese mice.

Alternate day feeding leads to improved glucose regulation on fasting days without significant weight loss in genetically obese mice. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 10;: Authors: Swoap SJ, Bingaman MJ, Hult EM, Sandstrom NJ Abstract Alternate day fasting (ADF) is effective for weight loss and increases insulin sensitivity in diet-induced obese rodents. However, the efficacy of ADF in genetic models of obesity has not been comprehensively studied. Mice that are deficient in leptin (ob/ob mice) are obese, diabetic, and are prone to deep bouts of torpor when fasted. We tested the hypotheses that an ADF protocol in ob/ob mice would result in 1) induction of torpor on fasted days, 2) minimal body weight loss if the mice experienced torpor, and 3) no improvement in glucose control in the absence of weight loss. Female ob/ob mice and littermate controls were assigned to either 1) ad libitum treatment or 2) ADF treatment consisting of fasting every other day, with ad libitum feeding between fasts. Over 19 days, littermate control mice on an ADF diet consumed the same amount of food as littermate control mice on an ad libitum diet, whereas ob/ob ADF mice consumed 37% less food than ob/ob mice on an ad libitum diet. Fasting days, but not fed days, led to torpor in both genotypes. Fasting days, but not fed days, led to weight loss in both genotypes relative to ad libitum controls. Fasting days, but not fed days, produced enhan...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research