Phenotypical and functional analysis of donor lymphocyte infusion products after long-term cryopreservation

Donor lymphocyte infusions, collected from peripheral blood by apheresis, are regularly used to re-establishing disease control in patients with impending or full relapse after allogeneic cell transplantation. The cryopreservation and thawing processes of the cellular products, required for clinical needs, result in a decreased cellular recovery. The aim of this study was to perform an integral analysis of phenotypic and functional characteristics in different cell populations, within cryopreserved products used for therapeutic purposes.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research