Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia

Publication date: Available online 9 July 2019Source: Stem Cell ResearchAuthor(s): Xinyue Bai, Xian-Jie Yang, Ling ChenAbstractPathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.
Source: Stem Cell Research - Category: Stem Cells Source Type: research