Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome

This Viewpoint reviews new findings presented at a 2019 NIH conference about neuroendocrine, metabolic, immunologic, and physiologic abnormalities that contribute to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research

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Conclusions: FSS and BDS are prevalent in the adult Danish population, and cases have high risk of poor self-perceived health, limitation in daily activities, and psychiatric comorbidity. These associations were particularly strong for cases with multiple FSS and multi-organ BDS. PMID: 31409218 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by myalgia and a sometimes severe limitation of physical activity and cognition. It is exacerbated by physical and mental activity. Its cause is unknown, but frequently starts with an infection. The eliciting infection (commonly infectious mononucleosis or an upper respiratory infection) can be more or less well diagnosed. Among the human herpesviruses (HHV-1-8), HHV-4 (Epstein-Barr virus; EBV), HHV-6 (including HHV-6A and HHV-6B) and HHV-7, have been implicated in the pathogenesis of ME/CFS. It was ther...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
By David Tuller, DrPH People who know little or nothing about the illness or cluster of illnesses variously called myalgic encephalomyelitis, chronic fatigue syndrome, CFS/ME, and ME/CFS can’t seem to stop writing stupid and ill-informed stories about it. And Professor Michael Sharpe seems to blame “Americans”–rather than his own disastrous research–for his current problems and […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs
Conclusion: Training and above all awareness raising strategies are needed to address health professionals' prejudices regarding the existence of contested illnesses such as Multiple Chemical Sensitivity. These prejudices hinder diagnosis and medical follow-up, and add negative emotions to the physical limitations already suffered by patients. IMPLICATIONS FOR REHABILITATION Multiple Chemical Sensitivity It is important to promote a compassionate and empathetic attitude among health providers, in order to avoid rejection and delegitimization of the experiences of women with Multiple Chemical Sensitivity. Multiple Chemical ...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cau...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
By David Tuller, DrPH Some Australian members of the GET/CBT ideological brigades have published yet more nonsense and drivel about “graded exercise therapy” as a treatment for ME/CFS, or what they are still calling “chronic fatigue syndrome.” The article, simply called “Chronic fatigue syndrome: graded exercise therapy,” is in a peer-reviewed journal from a reputable […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs
A 37-year-old woman with a history of depression and Roux-en-Y gastric bypass 16 years earlier presented with chronic fatigue, weight loss, irregular periods lasting 7 to 10 days, a vitamin B12 level of 149 pg/mL, and an iron level of 13 µg/dL. She reported a daily total calorie intake of less than 500 kcal and less than 20 g of protein. How do you interpret these results?
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Depression is a serious psychiatric disorder with an enormous socioeconomic burden, and it is commonly comorbid with pain, chronic fatigue, or other inflammatory diseases. Recent studies have shown that acupuncture is an effective therapeutic method for re...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Publication date: Available online 16 July 2019Source: Social Science &MedicineAuthor(s): Sara F. Milrad, Daniel L. Hall, Devika R. Jutagir, Emily G. Lattie, Sara J. Czaja, Dolores M. Perdomo, Gail Ironson, Brian D. Doss, Armando Mendez, Mary Ann Fletcher, Nancy Klimas, Michael H. AntoniAbstractRationaleRelationship dissatisfaction has been linked with worse health outcomes in many patient populations, though the mechanism(s) underlying this effect are unclear. Among patients with chronic fatigue syndrome (CFS) and their partners, there is evidence for a bi-directional association between poorer relationship satisfacti...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Purpose of review The current review aims to determine the recent evidence regarding cause, impact, effective treatment and prognosis of children and young people (CYP) affected by chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) at a time when the National Institute for Clinical Excellence guidelines in the United Kingdom are being reviewed and more research is called for worldwide. Recent findings CFS/ME is a debilitating illness with no clear cause. This review describes the heterogeneous clinical picture and the effects on the young person and family. Comorbidities such as mood disorders and pain are di...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ADOLESCENT MEDICINE: Edited by Sara F. Forman and Sarah Pitts Source Type: research
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