Prognostic impact of PIK3CA protein expression in triple negative breast cancer and its subtypes.

CONCLUSION: Despite conflicting results in the literature, our study clearly shows a better outcome of PIK3CA-expressing TNBC, independent of TNBC subtypes. PIK3CA expression in TNBC is not associated with specific clinical or diagnostic features. Further molecular studies and meta-analysis are warranted to clarify the prognostic and predictive role of PIK3CA protein expression.
PMID: 31270600 [PubMed - as supplied by publisher]

Source: Clinical Breast Cancer - July 2, 2019 Category: Cancer & Oncology Authors: Elfgen C, Reeve K, Moskovszky L, Güth U, Bjelic-Radisic V, Fleisch M, Tausch C, Varga Z Tags: J Cancer Res Clin Oncol Source Type: research