Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin  A nephropathy model mice

AbstractThe crude drugSojutsu, as defined by the Japanese Pharmacopoeia, is the rhizome ofAtractylodes lancea De Candolle,Atractylodes chinensis Koidzumi, or their interspecific hybrids (Asteraceae).Sojutsu is one of the traditional Kampo formulas, which are administered to patients suffering from stomach disorders, edema, and nephrotic syndrome. Although antiinflammatory effects ofSojutsu have been reported, its effects on the liver and kidney have not been extensively investigated. Here, we used aSojutsu sample identified asA.  chinensis rhizome and isolated several constituents from its ethyl acetate (EtOAc)-soluble fraction that decreased production of the proinflammatory mediator nitric oxide (NO) in interleukin  1β-treated rat hepatocytes. Among the constituents in this fraction, atractylodin showed the highest activity to suppress NO production, whereas hinesol, β-eudesmol, and α-bisabolol showed low activity. Atractylodin decreased the levels of inducible nitric oxide synthase, tumor necrosis factor  α, and lipocalin 2 messenger RNAs (mRNAs). The EtOAc-soluble fraction of theA.  chinensis rhizome extract was administered daily for 20  weeks to high immunoglobulin A (HIGA) mice, whose pathological findings resemble human immunoglobulin A nephropathy. This fraction decreased the weight of white adipose tissue and decreased mesangial proliferation and immunoglobulin A deposition in glomeruli. These result...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 18 October 2019Source: Journal of Food and Drug AnalysisAuthor(s): Heng-Hsiung Wu, Chao-Jung Chen, Pei-Yu Lin, Yu-Huei LiuAbstractMembranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA). Mice with MN exhibited proteinuria, histopathological changes, and accumulation of immune complexes in the glomerular basement membrane. Label-free proteomics ...
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
Authors: Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H Abstract We performed a renal biopsy for nephrotic syndrome in a patient with squamous cell lung carcinoma, which can worsen the prognosis. Chemoradiation therapy was effective for the cancer and proteinuria; we thus inferred that the nephrotic syndrome had been closely associated with the carcinoma. A pathological analysis of the kidney showed monoclonality for λ chain, satisfying the diagnostic criteria of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID); however, con...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Absence of a causative mutation represents the major risk factor for post-transplant recurrence in children with SRNS, while transplant can be curative in genetic SRNS. A prolonged time spent on dialysis before transplantation has no protective effect on the risk of relapse and should not be encouraged. Retransplantation represents a second chance after graft loss for recurrence. PMID: 31617157 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Pharmacogenomics,Volume 20, Issue 15, Page 1071-1083, October 2019.
Source: Future Medicine: Pharmacogenomics - Category: Genetics & Stem Cells Authors: Source Type: research
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Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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