4. Molecular characterizations of adult diffuse gliomas by the Oncoscan CNV Plus assay and next-generation sequencing (NGS)

Diffuse gliomas, including astrocytomas, oligodendrogliomas and glioblastomas (GBMs), are incurable. Recent molecular and cytogenomic profiling have enabled tumor classification for clinical management. To assess the genomic aberrations, we applied FISH, next generation sequencing (NGS) and the Oncoscan assay in 48 adult diffuse gliomas, including 9 oligodendrogliomas, 8 grade II/III astrocytomas, and 31 GBMs. Oligodendrogliomas were characterized by 1p/19q co-deletions and the IDH1 (R132H, n  = 8) or IDH2 (R172K, n = 1) mutations, with concurrent mutations in TERT, (62.5%), CIC (55.6%), and FUBP1 (22.2%).

Source: Cancer Genetics and Cytogenetics - March 31, 2019 Category: Genetics & Stem Cells Authors: Xinyan Lu, Madina Sukhanova, Juehua Gao, Craig Horbinski, Larry Jennings, Qinwei Mao, Eileen Bigio, Daniel Brat, Christina Appin Source Type: research