MALT1 ‐deletion in T‐cells protects against the development of auto‐immune arthritis, but causes spontaneous osteoporosis

ConclusionsOverall, our data highlight MALT1 a master regulator of T ‐cell activation relevant in autoimmune arthritis. Furthermore, MALT1‐deficiency leads to spontaneous osteoporosis which is associated with impaired Treg numbers.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - June 30, 2019 Category: Rheumatology Authors: Elisabeth Gilis, Djoere Gaublomme, Jens Staal, Koen Venken, Maarten Dhaenens, Stijn Lambrecht, Julie Coudenys, Tine Decruy, Nadia Schryvers, Yasmine Driege, Emilie Dumas, Annelies Demeyer, Am élie De Muynck, Jolanda van Hengel, Luc Van Hoor Tags: Full Length Source Type: research